Recent Publications from the Feig Lab

Research Publications Biochemistry Cell Biology Neuroscience

 

Wong R, Feig LA. 2016. Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras. Biochem Biophys Res Commun. Epub ahead of print.  books

Uzturk BG, Jin SX, Rubin B, Bartolome C, Feig LA. 2015. Ras-GRF1 regulates the HPA axis specifically in early-adolescent female mice. J Endocrinol. 227: 1-12.  Abstract in PubMed

Darcy MJ, Jin SX, Feig LA. 2014. R-Ras contributes to LTP and contextual discrimination. Neuroscience 277: 334-342. Abstract in PubMed

Darcy MJ, Trouche S, Jin SX, Feig LA. 2014. Ras-GRF2 mediates LTP, survival and response to an enriched environment of newborn neurons in the hippocampus. Hippocampus 24: 1317-1329. Abstract in PubMed

Jin SX, Bartolome C, Arai JA, Hoffman L, Uzturk BG, Kumar-Singh R, Waxham MN, Feig LA. 2014. Domain contributions to signaling specificity differences between Ras-Guanine Nucleotide Releasing Factor (Ras-GRF)1 and Ras-GRF2. J Biol Chem. 289: 16551-16664. Abstract in PubMed

Darcy MJ, Trouche S, Jin SX, Feig LA. 2013. Age-dependent role for ras-GRF1 in the late stages of adult neurogenesis in the dentate gyrus. Hippocampus 24: 315-325. Abstract in PubMed

Jin SX, Arai J, Tian X, Kumar-Singh R, Feig LA. 2013. Acquisition of contextual discrimination involves the appearance of a Ras-GRF1/p38 map kinase-mediated signaling pathway that promotes LTP. J Biol Chem. 288: 21703-21713. Abstract in PubMed

Saavedra-Rodríguez L, Feig LA. 2013. Chronic social instability induces anxiety and defective social interactions across generations. Biol Psychiatry 73: 44-53. Abstract in PubMed

Feig, LA. 2011. Regulation of neuronal function by Ras-GRF exchange factors. Genes Cancer 2: 306-319. Abstract in PubMed

Alt-Holland A, Sowalsky AG, Szwec-Levin Y, Shamis Y, Hatch H, Feig LA, Garlick JA. 2011. Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src. J Invest Dermatol. 131: 2306-2315. Abstract in PubMed

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA. 2011. RalA function in dermal fibroblasts is required for the progression of squamous cell carcinoma of the skin. Cancer Res. 71: 758-767.  Abstract in PubMed

Arai JA, Feig LA. 2011. Long-lasting and transgenerational effects of an environmental enrichment on memory formation. Brain Res Bull. 85: 30-35. Abstract in PubMed

Jin SX, Feig LA. 2010. Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling. PLoS One 5: e11732. Abstract in PubMed

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA. 2010. RalA suppresses early stages of Ras-induced squamous cell carcinoma progression. Oncogene 29: 45-55. books

Arai JA, Li S, Feig LA. 2009. Sos2 is dispensable for NMDA-induced Erk activation and LTP induction. Neurosci Lett. 8: 22-25. books

Arai J, Li S, Hartley DM, Feig LA. 2009. Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment. J Neuroscience. 29: 1496-1502. books

Hao Y, Wong, R,  Feig LA. 2008. RalGDS couples growth factor signaling to Akt activation. Mol Cell Biol. 28: 2851-2859. books

Li S, Feig LA, Hartley DM. 2007. A brief, but repeated, swimming protocol is sufficient to overcome amyloid B-protein inhibition of hippocampal long-term potentiation. Eur J Neuro. 26: 1289-1298. books

Li S, Tian X, Hartley DM, Feig LA. 2006. The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity. Curr Biol. 16: 1-11. books

Tian X, Feig LA. 2006. Age-dependent participation of Ras-GRF Pproteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons. J Biol Chem. 281: 7578-7582. books

Yu Y, Hao Y, Feig LA. 2006. The R-Ras GTPase mediates cross talk between estrogen and insulin signaling in breast cancer cells. Mol Cell Biol. 26: 6372-6380. books

Li S, Tian X, Hartley DM, Feig LA. 2006. Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression. J Neurosci. 26: 1721-1729. books

Feig LA. 2006. The odyssey of K-Ras. Mol Cell 21: 447-449. books

Wei J, Fain S, Harrison C, Feig LA, Baleja JD. 2006. Molecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain. Biochemistry. 45: 6826-6834. books

Lim KH, Baines A, Fiordalisi JJ, Shipitsin M, Feig LA, Cox AD, Der CJ, Counter CM. 2005. Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell. 7: 533-545. books

Rusanescu G, Yeng W, Bai A, Neel BG, Feig LA. 2005. Tyrosine phosphatase SHP-2 is a mediator of activity dependent neuronal excitotoxicity. EMBO J. 24: 1-10. books

Connolly BA, Rice J, Feig LA, Buchsbaum RJ. 2005. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. Mol Cell Biol. 25: 4602-4614. books

Shipitsin M, Feig LA. 2004. RalA but not RalB enhances polarized membrane delivery of E-cadherin to the basolateral surface of MDCK cells. Mol Cell Biol. 24: 5746-5756. books

Tian X, Gotoh T, Tsuji K, Lo E, Su H, Feig LA. 2004. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras/Erk/CREB. EMBO J. 23: 1567-1575. books

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