Recent Publications from the Davies Lab

Research Publications Neuroscience

 

Modgil A, Parakala ML, Ackley MA, Doherty JJ, Moss SJ, Davies PA. 2016. Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism. Neuropharmacology 113(Pt A):314-322.  books

Vien TN, Moss SJ, Davies PA. 2016. Regulating the efficacy of inhibition through trafficking of γ-aminobutyric acid type A receptors. Anesth Analg. 123: 1220-1227. Abstract in PubMed

Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ. 2016. Compromising KCC2 transporter activity enhances the development of continuous seizure activity. Neuropharmacology Epub ahead of print. books

Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ. 2016. Proteomic characterization of inhibitory synapses using a novel pHluorin-tagged GABAAR α2 subunit knock-in mouse. J Biol Chem. Epub ahead of print. books

Trattnig SM, Gasiorek A, Deeb TZ, Ortiz EJ, Moss SJ, Jensen AA, Davies PA. 2016. Copper and protons directly activate the zinc-activated channel. Biochem Pharmacol. 103: 109-117. books

Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. 2015. Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci USA 112: 14805-14810. books

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci USA  111: 3523-3528. books

Comenencia-Ortiz E, Moss SJ, Davies PA. 2014. Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions. Psychopharmacology (Berl) 231: 3453-3465. books

Abramian AM, Comenencia-Ortiz E, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ. 2014. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc Natl Acad Sci USA 111: 7132-7137. books

Davies PA 2014. GABA(A) receptor genetics and clinical pharmacology. Curr Anesthesiol Rep. 4:42-48. 

Deeb TZ, Nakamura Y, Frost GD, Davies PA, Moss SJ. 2013. Disrupted Cl- homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states. Eur J Neurosci. 38: 2453-2467. books

Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA. 2013. Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J Neurosci. 33: 7264-7273. books

Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA. 2012. Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors. Cell Rep. 2: 488-496. books

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