Recent Publications from the Kaplan Lab

Research Publications Cell Biology


Cairns DM, Boorgu DSSK, Levin M, Kaplan DL. 2018. Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells. Biol Open 7: pii: bio031807. doi: 10.1242/bio.031807.  books

Zhou W, Chen Y, Roh T, Lin Y, Ling S, Zhao S, Lin JD, Khalil N, Cairns DM, Manousiouthakis E, Tse M, Kaplan DL. 2018. Multifunctional bioreactor system for human intestine tissues. ACS Biomater. Sci Eng. 4: 231-239. books

Zheng Z, Wu J, Liu M, Wang H, Li C, Rodriguez MJ, Li G, Wang X, Kaplan DL. 2018. 3D bioprinting of self-standing silk-based bioink. Adv Healthc Mater. Epub ahead of print.  books

Bhunia BK, Kaplan DL, Mandal BB. 2017. Silk-based multilayered angle-ply annulus fibrosus construct to recapitulate form and function of the intervertebral disc. Proc Natl Acad Sci USA Epub ahead of print. books

Sundarakrishnan A, Chen Y, Black LD, Aldridge BB, Kaplan DL. 2017. Engineered cell and tissue models of pulmonary fibrosis. Adv Drug Deliv Rev. Epub ahead of print. books

Park YR, Sultan MT, Park HJ, Min Lee J, Ju HW, Lee OJ, Lee DJ, Kaplan DL, Park CH. 2017. NF-κB signaling is key in the wound healing processes of silk fibroin. Acta Biomater. Epub ahead of print. Abstract in PubMed

Chen Y, Zhou W, Roh T, Estes MK, Kaplan DL. 2017. In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses. PLoS One 12: e0187880. Abstract in PubMed

McGill M, Coburn JM, Partlow BP, Mu X, Kaplan DL. 2017. Molecular and macro-scale analysis of enzyme-crosslinked silk hydrogels for rational biomaterial design. Acta Biomater. 63: 76-84. Abstract in PubMed

Di Buduo CA, Soprano PM, Tozzi L, Marconi S, Auricchio F, Kaplan DL, Balduini A. 2017. Modular flow chamber for engineering bone marrow architecture and function. Biomaterials 146: 60-71. Abstract in PubMed

Abbott RD, Borowsky FE, Alonzo CA, Zieba A, Georgakoudi I, Kaplan DL. 2017. Variability in responses observed in human white adipose tissue models. J Tissue Eng Regen Med. Epub ahead of print. Abstract in PubMed

Guo J, Li C, Ling S, Huang W, Chen Y, Kaplan DL. 2017. Multiscale design and synthesis of biomimetic gradient protein/biosilica composites for interfacial tissue engineering. Biomaterials. 145: 44-55.  Abstract in PubMed

Du C, Collins W, Cantley W, Sood D, Kaplan DL. 2017. Tutorials for electrophysiological recordings in tissue engineering. ACS Biomater Sci Engineer. Abstract in PubMed

Wang Y, Aurelio D, Li W, Tseng P, Zheng Z, Li M, Kaplan DL, Liscidini M, Omenetto FG. 2017. Modulation of multiscale 3D lattices through conformational control: Painting silk inverse opals with water and light. Adv mater. 29: 38.  Abstract in PubMed

Plowright R, Belton DJ, Kaplan DL, Perry CC. 2017. Quantifying the efficiency of Hydroxyapatite Mineralising Peptides. Sci Rep. 7: 7681. Abstract in PubMed

Di Buduo CA, Kaplan DL, Balduini A. 2017. In vitro generation of platelets: Where do we stand? Transfus Clin Biol. 24: 273-276. Abstract in PubMed

Huang W, Tarakanova A, Dinjaski N, Wang Q, Xia X, Chen Y, Wong JY, Buehler MJ, Kaplan DL. 2017. Design of multistimuli responsive hydrogels using integrated modeling and genetically engineered silk-elastin-like proteins. Adv Funct Mater. 26: 4113-4123. Abstract in PubMed

Jacobsen MM, Tokareva OS, Ebrahimi D, Huang W, Ling S, Dinjaski N, Li D, Simon M, Staii C, Buehler MJ, Kaplan DL, Wong JY. 2017. Effect of terminal modification on the molecular assembly and mechanical properties of protein-based block copolymers. Macromol Biosci.  doi: 10.1002/mabi.201700095. Abstract in PubMed

Grasman JM, Kaplan DL. 2017. Human endothelial cells secrete neurotropic factors to direct axonal growth of peripheral nerves. Sci Rep. 7: 4092. Abstract in PubMed

Gosselin EA, Torregrosa T, Ghezzi CE, Mendelsohn AC, Gomes R, Funderburgh JL, Kaplan DL. 2017. Multi-layered silk film co-culture system for human corneal epithelial and stromal stem cells. Tissue Eng Regen Med. Epub ahead of print.  Abstract in PubMed

Bradner SA, Partlow BP, Cebe P, Omenetto FG, Kaplan DL. 2017. Fabrication of elastomeric silk fibers. Bioploymers doi: 10.1002/bip.23030.  Abstract in PubMed

Liu Y, Zheng Z, Gong H, Liu M, Guo S, Li G, Wang X, Kaplan DL. 2017. DNA preservation in silk. Biomater Sic. Epub ahead of print. Abstract in PubMed

Ding X, Yang G, Zhang W, Li G, Lin S, Kaplan DL, Jiang X. 2017. Increased stem cells delivered using a silk gel/scaffold complex for enhanced bone regeneration. Sci Rep. 7: 2175. Abstract in PubMed

Li D, Jacobsen M, Rim N, Backman D, Kaplan D, Wong JY 2017. Introducing biomimetic shear and ion gradients to microfluidic spinning improves silk fiber strength. Biofabrication 9: 025025. Abstract in PubMed

Abbonante V, Di Buduo CA, Gruppi C, De Maria C, Spedden E, De Acutis A, Staii C, Raspanti M, Vozzi G, Kaplan D, Moccia F, Ravid K, Balduini A. 2017. A new path to platelet production through matrix sensing. Haematologica 102: 1150-1160. Abstract in PubMed

Thurber AE, Nelson M, Frost CL, Levin M, Brackenbury WJ, Kaplan DL. 2017. IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines. Oncotarget 8: 42382-42397.  Abstract in PubMed

Cebe P, Partlow BP, Kaplan DL, Wurm A, Zhuravlev E, Schick C. 2017. Silk I and silk II studied by fast scanning calorimetry. Acta Biomater. 55: 323-332.  Abstract in PubMed

Landry MJ, Applegate MB, Bushuyev OS, Omenetto FG, Kaplan DL, Cronin-Golomb M, Barrett CJ. 2017. Photo-induced structural modification of silk gels containing azobenzene side groups. Soft Matter. 13: 2903-2906 Abstract in PubMed

Raia NR, Partlow BP, McGill M, Kimmerling EP, Ghezzi CE, Kaplan DL. 2017. Enzymatically crosslinked silk-hyaluronic acid hydrogels. Biomaterials 131: 58-67. Abstract in PubMed

Tarakanova A, Huang W, Weiss AS, Kaplan DL, Buehler MJ. 2017. Computational smart polymer design based on elastin protein mutability. Biomaterials 127: 49-60.  Abstract in PubMed

Tseng P, Napier B, Zhao S, Mitropoulos AN, Applegate MB, Marelli B, Kaplan DL, Omenetto FG. 2017. Directed assembly of bio-inspired hierarchical materials with controlled nanofibrillar architectures. Nat Nanotechnol. 12: 474-480. Abstract in PubMed

Huang W, Ebrahimi D, Dinjaski N, Tarakanova A, Buehler MJ, Wong JY, Kaplan DL. 2017. Synergistic integration of experimental and simulation approaches for the de novo design of silk-based materials. Ass Chem Res. 50: 866-876.  Abstract in PubMed

Yang L, Zheng Z, Qian C, Wu J, Liu Y, Guo S, Li G, Liu M, Wang X, Kaplan DL. 2017. Curcumin-functionalized silk biomaterials for anti-aging utility. J Colloid Interface Sci. 496: 66-77.  Abstract in PubMed

Ghezzi CE, Marelli B, Omenetto FG, Funderburgh JL, Kaplan DL. 2017. 3D functional corneal stromal tissue equivalent based on corneal stromal stem cells and multi-layered silk film architecture. PLoS One 12: e0169504.  Abstract in PubMed

DeCicco RePass MA, Chen Y, Lin Y, Zhou W, Kaplan DL, Ward HD. 2017. A novel bioengineered 3D human intestinal model for long-term infection of Cryptosporidium parvum. Infect Immun. 85: e00731-16. Abstract in PubMed

Marelli B, Patel N, Duggan T, Perotto G, Shirman E, Li C, Kaplan DL, Omenetto FG. 2017. Programming function into mechanical forms by directed assembly of silk bulk materials. Proc Natl Acad Sci USA 114: 451-456. Abstract in PubMed

Li C, Kilpatrick CD, Kenwood SS, Glettig DL, Glod DJ, Mallette J, Strunk MR, Chang J, Angle SR, Kaplan DL. 2017. Assessment of multipotent mesenchymal stromal cells in bone marrow aspirate from human calcaneus. J Foot Ankle Surg. 56: 42-56. Abstract in PubMed

Dinjaski N, Ebrahimi D, Qin Z, Giordano JE, Ling S, Buehler J M, Kaplan DL. 2016. Predicting rates of in vivo degradation of recombinant spider silk proteins. J Tissue Eng Regen Med. doi: 10.1002/term.2380.  Abstract in PubMed

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I. 2016. Automated quantification of three-dimensional organization of fiber-like structures in biological tissues. Biomaterials 116: 34-47.  Abstract in PubMed

Brown JE, Moreau JE, Berman AM, McSherry HJ, Coburn JM, Schmidt DF, Kaplan DL. 2017. Shape memory silk protein sponges for minimally invasive tissue regeneration. Adv Healthc Mater. doi: 10.1002/adhm.201600762E. Abstract in PubMed

Wang RY, Abbott RD, Zieba A, Borowsky FE, Kaplan DL. 2016. Development of a three-dimensional adipose tissue model for studying embryonic exposures to obesogenic chemicals. Ann Biomed Eng. 45: 1807-1818. Abstract in PubMed

He M, Storr-Paulsen T, Wang AL, Ghezzi CE, Wang S, Fullana M, Karamichos D, Utheim TP, Islam R, Griffith M, Islam MM, Hodges RR, Wnek GE, Kaplan DL, Dartt DA. 2016. Artificial polymeric xcaffolds as extracellular matrix substitutes for autologous conjunctival goblet cell expansion. Invest Opthalmol Vis Sci. 57: 6134-6146. Abstract in PubMed

Dadwal U, Falank C, Fairfield H, Linehan S, Rosen CJ, Kaplan DL, Sterling J, Reagan MR. 2016. Tissue-engineered 3D cancer-in-bone modeling: silk and PUR protocols. Bonekey Rep. 5:842.  Abstract in PubMed

Kumar M, Coburn J, Kaplan DL, Mandal BB. 2016. Immuno-informed 3D silk biomaterials for tailoring biological responses. ACS Appl Mater Interfaces 8: 29310-29322.  Abstract in PubMed

Coburn J, Harris J, Zakharov AD, Poirier J, Ikegaki N, Kajdacsy-Balla A, Pilichowska M, Lyubimov AV, Shimada H, Kaplan DL, Chiu B. 2016. Implantable chemotherapy-loaded silk protein materials for neuroblastoma treatment. Int J Cancer 140: 726-735.  Abstract in PubMed

Pereira AM, Machado R, da Costa A, Ribeiro A, Collins T, Gomes AC, Leonor IB, Kaplan DL, Reis RL, Casal M. 2017. Silk-based biomaterials functionalized with fibronectin type II promotes cell adhesion. Acta Biomater. 47: 50-59. Abstract in PubMed

Wang S, Ghezzi CE, Gomes R, Pollard RE, Funderburgh JL, Kaplan DL. 2016. In vitro 3D corneal tissue model with epithelium, stroma, and innervation. Biomaterials 9: 1-9. Abstract in PubMed

Milan PB, Lotfibakhshaiesh N, Joghataie MT, Ai J, Pazouki A, Kaplan DL, Kargozar S, Amini N, Hamblin MR, Mozafari M, Samadikuchaksaraei A. 2016. Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. Acta Biomater. 45: 234-246. Abstract in PubMed

Teuschl AH, Zipperle J, Huber-Gries C, Kaplan DL. 2017. Silk fibroin based carrier system for delivery of fibrinogen and thrombin as coagulant supplements. J Biomed Mater Res A 105: 687-696. Abstract in PubMed

Li C, Hotz B, Ling S, Guo J, Haas DS, Marelli B, Omenetto F, Lin SJ, Kaplan DL. 2016. Regenerated silk materials for functionalized silk orthopedic devices by mimicking natural processing. Biomaterials 110: 24-33. Abstract in PubMed

Harris JC, Coburn JM, Kajdacsy-Balla A, Kaplan DL, Chiu B. 2016. Sustained delivery of vincristine inside an orthotopic mouse sarcoma model decreases tumor growth. J Pediatr Surg. 51: 2058-2062. Abstract in PubMed

Brouki Milan P, Lotfibakhshaiesh N, Joghataie MT, Ai J, Pazouki A, Kaplan DL, Kargozar S, Amini N, Hamblin MR, Mozafari M, Samadikuchaksaraei A. 2016. Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. Acta Biomater. 45: 234-246. Abstract in PubMed

Cairns DM, Chwalek K, Moore YE, Kelley MR, Abbott RD, Moss S, Kaplan DL. 2016. Expandable and rapidly differentiating human induced neural stem cell lines for multiple tissue Engineering applications. Stem Cell Rep. 7: 557-570. Abstract in PubMed

Zhang Q, Yan S, You R, Kaplan DL, Liu Y, Qu J, Li X, Li M, Wang X. 2016. Multichannel silk protein/laminin grafts for spinal cord injury repair. J Biomed Mater Res A 104: 3045-3057.  Abstract in PubMed

Stoppel WL, Gao AE, Greaney AM, Partlow BP, Bretherton RC, Kaplan DL, Black LD 3rd. 2016. Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response. J Biomed Mater Res A 104: 3058-3072.  Abstract in PubMed

Yigit S, Yu H, An B, Hamaia S, Farndale RW, Kaplan DL, Lin YS, Brodsky B. 2016. Mapping the effect of Gly mutations in collagen on α2β1 integrin binding. J Biol Chem. 291: 19196-191207. Abstract in PubMed

Ding ZZ, Fan ZH, Huang XW, Bai SM, Song DW, Lu Q, Kaplan DL. 2016. Bioactive natural protein-hydroxyapatite nanocarriers for optimizing osteogenic differentiation of mesenchymal stem cells. J Mater Chem B Mater Biol Med. 4: 3555-3561. Abstract in PubMed

Sundarakrishnan A, Acero EH, Coburn J, Chwalek K, Partlow B, Kaplan DL. 2016. Phenol red-silk tyrosine cross-linked hydrogels. Acta Biomater. 42: 102-113.  Abstract in PubMed

Ling S, Li C, Jin K, Kaplan DL, Buehler MJ. 2016. Liquid Exfoliated natural silk nanofibrils: Applications in optical and electrical devices. Adv Mater. 28: 7783-7790.  Abstract in PubMed

Han H, Ning H, Liu S, Lu Q Prof, Fan Z, Lu H, Lu G, Kaplan DL. 2016. Silk biomaterials with vascularization capacity. Adv Funct Mater. 26: 421-436.  Abstract in PubMed

Zheng Z, Guo S, Liu Y, Wu J, Li G, Liu M, Wang X, Kaplan D. 2016. Lithium-free processing of silk fibroin. J Biomater Appl. 31: 450-463. Abstract in PubMed

Burke KA, Brenckle MA, Kaplan DL, Omenetto FG. 2016. Evaluation of the spectral response of functionalized silk inverse opals as colorimetric immunosensors. ACS Appl Mater Interfaces. 8: 16218-16226.  Abstract in PubMed

Golding A, Guay JA, Herrera-Rincon C, Levin M, Kaplan DL. 2016. A tunable silk hydrogel device for studying limb regeneration in adult Xenopus laevis. PLoS One 11: e0155618.  Abstract in PubMed

Ghezzi CE, Wang L, Behlau I, Rnjak-Kovacina J, Wang S, Goldstein MH, Liu J, Marchant JK, Rosenblatt MI, Kaplan DL. 2016. Degradation of silk films in multipocket corneal stromal rabbit models. J Appl Biomater Funct Mater. 14: e266-e276. Abstract in PubMed

Wu J, Zheng Z, Li G, Kaplan DL, Wang X. 2016. Control of silk microsphere formation using polyethylene glycol (PEG). Acta Biomater. 39: 156-168. Abstract in PubMed

Abbott RD, Wang RY, Reagan MR, Chen Y, Borowsky FE, Zieba A, Marra KG, Rubin JP, Ghobrial IM, Kaplan DL. 2016. The use of silk as a scaffold for mature, sustainable unilocular adipose 3D tissue engineered systems. Adv Healthc Mater. 5: 1667-1677. Abstract in PubMed

Kluge JA, Li AB, Kahn BT, Michaud DS, Omenetto FG, Kaplan DL. 2016. Silk-based blood stabilization for diagnostics. Proc Natl Acad Sci USA 113: 5892-5897. Abstract in PubMed

Stoichevska V, An B, Peng YY, Yigit S, Vashi AV, Kaplan DL, Werkmeister JA, Dumsday GJ, Ramshaw JA. 2016. Formation of multimers of bacterial collagens through introduction of specific sites for oxidative cross-linking. J Biomed Mater Res A 104: 2369-2376. Abstract in PubMed

Marelli B, Brenckle MA, Kaplan DL, Omenetto FG. 2016. Silk fibroin as edible coating for perishable food preservation. Sci Rep. 6: 25623. Abstract in PubMed

Koolen PG, Haas D, Kim K, Fox S, Ibrahim AM, Kim P, Kaplan DL, Lin SJ. 2016. Increased osteoid formation in BMP-2-loaded silk-based screws. Plast Reconstr Surg. 137: 808e-817e. Abstract in PubMed

Calabrese R, Raia N, Huang W, Ghezzi CE, Simon M, Staii C, Weiss AS, Kaplan DL. 2016. Silk-ionomer and silk-tropoelastin hydrogels as charged three-dimensional culture platforms for the regulation of hMSC response. J Tissue Eng Regen Med. Epub ahead of print. Abstract in PubMed

Zhao S, Chen Y, Partlow BP, Golding AS, Tseng P, Coburn J, Applegate MB, Moreau JE, Omenetto FG, Kaplan DL. 2016. Bio-functionalized silk hydrogel microfluidic systems. Biomaterials 93: 60-70. Abstract in PubMed

Applegate MB, Partlow BP, Coburn J, Marelli B, Pirie C, Pineda R, Kaplan DL, Omenetto FG. 2016. Silk fibroin: Photocrosslinking of silk fibroin using riboflavin for ocular prostheses. Adv Mater. 28: 2464. Abstract in PubMed

Plowright R, Dinjaski N, Zhou S, Belton DJ, Kaplan DL, Perry CC. 2016. Influence of silk-silica fusion protein design on silica condensation in vitro and cellular calcification. RSC Adv. 6: 21776-21788. Abstract in PubMed

Frazier TP, Bowles A, Lee S, Abbott R, Tucker HA, Kaplan D, Wang M, Strong A, Brown Q, He J, Bunnell BA, Gimble JM. 2016. Serially transplanted non-pericytic CD146- adipose stromal/stem cells in silk bioscaffolds regenerate adipose tissue in vivo. Stem Cells 34: 1097-1111. Abstract in PubMed

Li C, Levin M, Kaplan DL. 2016. Bioelectric modulation of macrophage polarization. Sci Rep. 6: 21004. Abstract in PubMed

Abbott RD, Kimmerling EP, Cairns DM, Kaplan DL. 2016. Silk as a biomaterial to support long-term three-dimensional tissue cultures. ACS Appl Mater Interfaces Epub ahead of print. Abstract in PubMed

Applegate MB, Partlow BP, Coburn J, Marelli B, Pirie C, Pineda R, Kaplan DL, Omenetto FG. 2016. Photocrosslinking of silk fibroin using riboflavin for ccular prostheses. Adv Mater. 28: 2417-2420. Abstract in PubMed

Belanger K, Dinis TM, Taourirt S, Vidal G, Kaplan DL, Egles C. 2016. Recent strategies in tissue engineering for guided peripheral nerve regeneration. Macromol Biosci. 16: 472-481. Abstract in PubMed

Partlow BP, Tabatabai AP, Leisk GG, Cebe P, Blair DL, Kaplan DL. 2016. Silk fibroin degradation related to rheological and mechanical properties. Macromol Biosci. Epub ahead of print. Abstract in PubMed

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research