Recent Publications from the Chishti Lab

 

Research Publications Cell Biology  Microbiology Pharmacology Physiology

  

Schiemer J, Bohm A, Lin L, Merrill-Skoloff G, Flaumenhaft R, Huang JS, Le Breton GC, Chishti AH. 2016. Gα13 switch region 2 relieves talin autoinhibition to activate IαIbβ3 integrin. J Biol Chem. 291: 26598-26612.  books

Ranjan R, Karpurapu M, Rani A, Chishti AH, Christman JW. 2016. Hemozoin regulates iNOS expression by modulating the transcription factor NF-κB in macrophages. Biochem Mol Biol J. 2: pii: 10.  books

Nwankwo JO, Lei J, Xu J, Rivera A, Gupta K, Chishti AH. 2016. Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease. Haematologica 101: e397-e400.  books

Lu Y, Hanada T, Fujiwara Y, Nwankwo JO, Wieschhaus AJ, Hartwig J, Huang S, Han J, Chishti AH. 2016. Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood 128: 93-103.  books

Howatt DA, Balakrishnan A, Moorleghen JJ, Muniappan L, Rateri DL, Uchida HA, Takano J, Saido TC, Chishti AH, Baud L, Subramanian V. 2016. Leukocyte calpain deficiency reduces angiotensin II-induced inflammation and atherosclerosis but not abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 36: 835-845.  books

Srinivasan S, Schiemer J, Zhang X, Chishti AH, Le Breton GC. 2015. Gα13 switch region 2 binds to the talin head domain and activates αIIbβ3 integrin in human platelets. J Biol Chem. 290: 25129-25139.  books

Baldwin MR, Li X, Hanada T, Liu SC, Chishti AH. 2015. Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells. Blood 125: 2704-2711.  books

Chishti AH. 2015. Malaria selectively targets pregnancy receptors. Blood 125: 217-218. books

Baldwin M, Yamodo I, Ranjan R, Li X, Mines G, Marinkovic M, Hanada T, Oh SS, Chishti AH. 2014. Human erythrocyte Band 3 functions as a receptor for the sialic acid-independent invasion of Plasmodium falciparum. Role of the RhopH3-MSP1 complex. Biochim Biophys Acta 1843: 2855-2870. books

Baldwin M, Russo C, Li X, Chishti AH. 2014. Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis. Biochem Biophys Res Commun. 450: 1427-1432. books

Wang Y, Briz V, Chishti A, Bi X, Baudry M. 2013. Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 33: 18880-18892. books

Subramanian V, Moorleghen JJ, Balakrishnan A, Howatt DA, Chishti AH, Uchida HA. 2013. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS One 8: e72214. books

Mattheij NJ, Gilio K, van Kruchten R, Jobe SM, Wieschhaus AJ, Chishti AH, Collins P, Heemskerk JW, Cosemans JM. 2013. Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets. J Biol Chem. 288: 13325-13336. books

De Franceschi L, Franco RS, Bertoldi M, Brugnara C, Matté A, Siciliano A, Wieschhaus AJ, Chishti AH, Joiner CH. 2013. Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. FASEB J. 27: 750-759. books

Wieschhaus AJ, Le Breton GC, Chishti AH. 2012. Headpiece domain of dematin regulates calcium mobilization and signaling in platelets. J Biol Chem. 287: 41218-41231. books

Wieschhaus A, Khan A, Zaidi A, Rogalin H, Hanada T, Liu F, De Franceschi L, Brugnara C, Rivera A, Chishti AH. 2012. Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. Biochem J. 448:141-152. books

Yamada KH, Kozlowski DA, Seidl SE, Lance S, Wieschhaus AJ, Sundivakkam P, Tiruppathi C, Chishti I, Herman IM, Kuchay SM, Chishti AH. 2012. Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress. J Biol Chem. 287: 13182-13193. books

Li X, Marinkovic M, Russo C, McKnight CJ, Coetzer TL, Chishti AH. 2012. Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells. Mol Biochem Parasitol. 183: 23-31. books

Lorand L, Murthy SN, Khan AA, Xue W, Lockridge O, Chishti AH. 2011. Transglutaminase-mediated remodeling of the human erythrocyte membrane skeleton: relevance for erythrocyte diseases with shortened cell lifespan. Adv Enzymol Relat Areas Mol Biol.78: 385-414. books

Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. 2011. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol. 31: 4097-4106. books

Liu F, Khan AA, Chishti AH, Ostafin AE. 2011. Atomic force microscopy demonstration of cytoskeleton instability in mouse erythrocytes with dematin-headpiece and β-adducin deficiency. Scanning 33: 426-436. books

Huckaba TM, Gennerich A, Wilhelm JE, Chishti AH, Vale RD. 2011. Kinesin-73 is a processive motor that localizes to Rab5-containing organelles. J Biol Chem. 286: 7457-7469. books

Tsurudome K, Tsang K, Liao EH, Ball R, Penney J, Yang JS, Elazzouzi F, He T, Chishti A, Lnenicka G, Lai EC, Haghighi AP. 2010. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. Neuron 68: 879-893. books

Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW. 2010. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc Natl Acad Sci USA. 107: 20346-20351.  books

Kang MY, Zhang Y, Matkovich SJ, Diwan A, Chishti AH, Dorn GW 2nd. 2010. Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains. Circ Res. 107: 903-912  books

Quinn BJ, Welch EJ, Kim AC, Lokuta MA, Huttenlocher A, Khan AA, Kuchay SM, Chishti AH. 2009. Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proc Natl Acad Sci USA. 106: 19842-19847.  books

Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti AH, Hanada T, Quattrini A, Previtali SC, Biffi A, Bolino A. Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. 2009. J Neurosci. 29: 8858-8870.  books

Mohseni M, Chishti AH. 2009. Regulatory models of RhoA suppression by dematin, a cytoskeletal adaptor protein. Cell Adh Migr. 3: 191-194.  books

Chen L, Jiang ZG, Khan AA, Chishti AH, McKnight CJ. 2009. Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. Protein Sci. 18: 629-636.  books

Mays TA, Sanford JL, Hanada T, Chishti AH, Rafael-Fortney JA. 2009. Glutamate receptors localize postsynaptically at neuromuscular junctions in mice. Muscle Nerve. 39: 343-349.  books

Li X, Chen H, Bahamontes-Rosa N, Kun JF, Traore B, Crompton PD, Chishti AH. 2009. Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria. Biochem Biophys Res Commun. 380:454-459.  books

Seo PS, Quinn BJ, Khan AA, Zeng L, Takoudis CG, Hanada T, Bolis A, Bolino A, Chishti AH. 2009. Identification of erythrocyte p55/MPP1 as a binding partner of NF2 tumor suppressor protein/Merlin. Exp Biol Med. 234: 255-262.  books

Seo PS, Jeong JJ, Zeng L, Takoudis CG, Quinn BJ, Khan AA, Hanada T, Chishti AH. 2009. Alternatively spliced exon 5 of the FERM domain of protein 4.1R encodes a novel binding site for erythrocyte p55 and is critical for membrane targeting in epithelial cells. Biochim Biophys Acta. 1793: 281-289.  books

Li X, Chen H, Khan AA, Lauterbach SB, Lanzillotti R, Rai PR, Kane RS, Coetzer TL, Chishti AH. 2008. Receptor-based identification of an inhibitory peptide against blood stage malaria. Biochem Biophys Res Commun. 376: 489-493.  books

Unno K, Hanada T, Chishti AH. 2008. Functional involvement of human discs large tumor suppressor in cytokinesis. Exp Cell Res. 314: 3118-3129.  books

Mohseni M, Chishti AH. 2008. The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation. Mol Cell Biol. 28: 4712-4718.  books

Sha D, Jin Y, Wu H, Wei J, Lin CH, Lee YH, Buddhala C, Kuchay S, Chishti AH, Wu JY. 2008. Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase. Brain Res. 1207: 9-18.  books

Khan AA, Hanada T, Mohseni M, Jeong JJ, Zeng L, Gaetani M, Li D, Reed BC, Speicher DW, Chishti AH. 2008. Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1. J Biol Chem. 283: 14600-14609.  books

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