Recent Publications from the Chen Lab

 

Research Publications Cell Biology

 

Zhang J, Chen J. 2016. Bone tissue regeneration - Application of mesenchymal stem cells and cellular and molecular mechanisms. Curr Stem Cell Res Ther. Epub ahead of print. books

Zheng L, Tu Q, Meng S, Zhang L, Yu L, Song J, Hu Y, Sui L, Zhang J, Dard M, Cheng J, Murray D, Lian J, Stein G, Chen J. 2016. Runx2/DICER/miRNA pathway in regulating osteogenesis. J Cell Physiol. 232: 182-191. books

Han Q, Yang P, Wu Y, Meng S, Sui L, Zhang L, Yu L, Tang Y, Jiang H, Xuan D, Kaplan DL PhD, Kim SH, Tu Q, Chen J. 2015. Epigenetically modified bone marrow stromal cells (BMSCs) in silk scaffolds promote craniofacial bone repair and wound healing. Tissue Eng Part A 21: 2156-2165. books

Yu L, Tu Q, Han Q, Zhang L, Sui L, Zheng L, Meng S, Tang Y, Xuan D, Zhang J, Murray D, Shen Q, Cheng J, Kim SH, Dong LQ, Valverde P, Cao X, Chen J. 2014. Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway - an approach for treating bone disease in diabetes. Stem Cells 33: 240-252. books

Zhang L, Meng S, Tu Q, Yu L, Tang Y, Dard MM, Kim SH, Valverde P, Zhou X, Chen J. 2014. Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice. PLoS One 9: e97824. books

Wu Y, Tu Q, Valverde P, Zhang J, Murray D, Dong L, Cheng J, Jiang H, Rios M, Morgan E, Tang Z, Chen J. 2014. Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice. Am J Physiol Endocrinol Metab. 306: E1418-E1430. books

Meng S, Zhang L, Tang Y, Tu Q, Zheng L, Yu L, Murray D, Cheng J, Kim SH, Zhou X, Chen J. 2014. BET inhibitor JQ1 blocks inflammation and bone destruction. J Dent Res. 93: 657-662. books

Yan SG, Zhang J, Tu Q, Ye JH, Luo E, Schuler M, Dard MM, Yu Y, Murray D, Cochran DL, Kim SH, Yang P, Chen J. 2013. Transcription factor and bone marrow stromal cells in osseointegration of dental implants. Eur Cell Mater. 26: 263-271. books

Luo E, Hu J, Bao C, Li Y, Tu Q, Murray D, Chen J. 2012. Sustained release of adiponectin improves osteogenesis around hydroxyapatite implants by suppressing osteoclast activity in ovariectomized rabbits. Acta Biomater. 8: 734-743. books

Yan SG, Zhang J, Tu QS, Ye JH, Luo E, Schuler M, Kim MS, Griffin T, Zhao J, Duan XJ, Cochran DJ, Murray D, Yang PS, Chen J. 2011. Biomaterials. 32: 8676-8683. books

Ye JH, Xu YJ, Gao J, Yan SG, Zhao J, Tu Q, Zhang J, Duan XJ, Sommer CA, Mostoslavsky G, Kaplan DL, Wu YN, Zhang CP, Wang L, Chen J. 2011. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials. 32: 2065-5076. books

Zhang J, Tu Q, Grosschedl R, Kim MS, Griffin T, Drissi H, Yang P, Chen J. 2011. Roles of SATB2 in osteogenic differentiation and bone regeneration. Tissue Eng Part A. 17: 1767-1776. books

Zhang J, Tu Q, Bonewald LF, He X, Stein G, Lian J, Chen J. 2011. Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1. J Bone Miner Res. 26: 1953-1963. books

Tu Q, Zhang J, Dong LQ, Saunders E, Luo E, Tang J, Chen J. 2011. Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1. J Biol Chem. 286: 12542-12553. books

Duan X, Tu Q, Zhang J, Ye J, Sommer C, Mostoslavsky G, Kaplan D, Yang P, Chen J. 2011. Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. J Cell Physiol. 226: 150-157. books

Zhang J, Tu Q, Bonewald LF, He X, Stein G, Lian J, Chen J. 2011. Effects of miR-335-5p in modulating osteogenic differentiation by specifically down-regulating Wnt antagonist DKK1. J Bone Miner Res. 26: 1953-1963. books

Tu Q, Zhang J, Saunders E, Liu F, Dong LQ and Chen, J. 2011. AKT1 is a downstream target of APPL1 mediating adiponectin signaling and inhibition in osteoclasts. J Biol Chem, 286: 12542-12553.

Zhang J, Tu Q, Grosschedl R, Kim MS, Griffin T, Drissi H, Yang P, Chen J. 2011. Roles of SATB2 in Osteogenic Differentiation and Bone Regeneration. Tissue Eng Part A. 17: 1767-1776. books

Ye JH, Xu YJ, Gao J, Yan SG, Zhao J, Tu Q, Zhang J, Duan XJ, Sommer CA, Mostoslavsky G, Kaplan DL, Wu YN, Zhang CP, Wang L, Chen J. 2011. Critical-size calvarial bone defects healing in a mouse model with silk scaffolds and SATB2-modified iPSCs. Biomaterials 32: 5065-5076. books

Xu B, Zhang J, Brewer E, Tu Q, Yu L, Tang J, Krebsbach P, Wieland M, Chen J. 2009. Osterix enhances BMSC-associated osseointegration of implants. J Dent Res 88: 1003-1007. books

Zhao J, Zhang Z, Wang S, Sun X,Zhang X, Chen J, Kaplan DL, Jiang X.  2009. Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines. Bone 45: 517-527. books

Jiang X, Zhao J, Wang S, Sun X, Zhang X, Chen J, Kaplan DL, Zhang Z. 2009. Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs. Biomaterials 30: 4522– 4532. books

Zhang J, Tu Q, Chen J. 2009. Applications of transgenics in studies of bone sialoprotein. J Cell Physiol. 220: 30-34. books

Tu Q, Zhang J, Fix A, Brewer E, Li YP, Zhang ZY, Chen J. 2009. Targeted overexpression of BSP in osteoclasts promotes bone metastasis of breast cancer cells. J Cell Physiol. 218: 135-145. books

Zhao Y, Wang C, Li S, Song H, Wei F, Pan K, Zhu K, Yang P, Tu Q, Chen J. 2008. Expression of osterix in mechanical stress-induced osteogenic differentiation of periodontal ligament cells in vitro. Eur J Oral Sci. 116: 199-206. books

Tu Q, Zhang J, Paz J, Wade K, Yang P, Chen J. 2008. Haploinsufficiency of Runx2 results in bone formation decrease and different BSP expression pattern changes in two transgenic mouse models. J Cell Physiol. 217: 40-47. books

Valverde P, Zhang J, Fix A, Zhu J, Ma W, Tu Q, Chen J. 2008. Overexpression of bone sialoprotein leads to an uncoupling of bone formation and bone resorption in mice. J Bone Miner Res. 23: 1775-1788. books

Li S, Tu Q, Zhang J, Stein G, Lian J, Yang PS, Chen J. 2008. Systemically transplanted bone marrow stromal cells contributing to bone tissue regeneration. J Cell Physiol. 215: 204-209. books

Zhang J, Zhu J, Valverde P, Li L, Pageau S, Tu Q, Nishimura R, Yoneda T, Yang P, Zheng W, Ma W, Chen J. 2008. Phenotypic analysis of Dlx5 overexpression in post-natal bone. J Dent Res 87: 45-50. books

Tu Q, Zhang J, James L, Dickson J, Tang J, Yang P, Chen J. 2007.  Cbfa1/Runx2-deficiency delays bone wound healing and locally delivered Cbfa1/Runx2 promotes bone repair in animal models. Wound Repair Regen. 15: 404–412. books

Yen CA, Griffin TJ, Cheung WS and Chen J.  2007. Effects of platelet concentrate on palatal wound healing after connective tissue graft harvesting.  J Periodontol.  78: 601-610. books

Tu Q, Valverde P, Li S, Zhang J, Yang PS and Chen J. 2007. Osterix overexpression in bone marrow stromal cells stimulates healing of critical-sized defects in murine calvarial bone. Tissue Eng. 13: 2431-2440. books

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