Recent Publications from the Camilli Lab


Research Publications Microbiology


Molina-Quiroz RC, Silva-Valenzuela C, Brewster J, Castro-Nallar E, Levy SB, Camilli A. 2018. Cyclic AMP regulates bacterial persistence through repression of the oxidative stress response and SOS-dependent DNA repair in uropathogenic Escherichia coli. MBio 9 (1). books

Silva-Valenzuela CA, Lazinski DW, Kahne SC, Nguyen Y, Molina-Quiroz RC, Camilli A. 2017. Growth arrest and a persister state enable resistance to osmotic shock and facilitate dissemination of Vibrio cholerae. ISME J. Epub ahead of print. books

Yen M, Camilli A. 2017. Mechanisms of the evolutionary arms race between Vibrio cholerae and Vibriophage clinical isolates. Int Microbiol. 20: 116-120.  books

Li P, Kinch LN, Ray A, Dalia AB, Cong Q, Nunan LM, Camilli A, Grishin NV, Salomon D, Orth K. 2017. Acute Hepatopancreatic Necrosis Disease (AHPND)-causing Vibrio parahaemolyticus strains maintain an antibacterial Type VI Secretion System with versatile effector repertoires. Appl Environ Microbiol. Epub ahead of print.  books

Yen M, Cairns LS, Camilli A. 2017. A cocktail of three virulent bacteriophages prevents Vibrio cholerae infection in animal models. Nat Commun. 8: 14187. books

Wang Z, Lazinski DW, Camilli A. 2016. Immunity Provided by an outer membrane vesicle cholera vaccine is due to O-antigen-specific antibodies inhibiting bacterial motility. Infect Immun. 85: pii: e00626-16. books

Molina-Quiroz RC, Lazinski DW, Camilli A, Levy SB. 2016. Transposon-sequencing analysis unveils novel genes involved in the generation of persister cells in uropathogenic Escherichia coli. Antimicrob Agents Chemother. 60: 6907-6910.  books

Fleming E, Camilli A. 2016. ManLMN is a glucose transporter and central metabolic regulator in Streptococcus pneumoniae. Mol Microbiol. 102: 467-487.  books

Troy EB, Lin T, Gao L, Lazinski DW, Lundt M, Camilli A, Norris SJ, Hu LT. 2016. Global Tn-seq analysis of carbohydrate utilization and vertebrate infectivity of Borrelia burgdorferi. Mol Microbiol. 101: 1003-1023.  books

Curtis A, Blackburn JK, Smiley SL, Yen M, Camilli A, Alam MT, Ali A, Morris JG. 2016. Mapping to support fine scale epidemiological cholera investigations: A case study of spatial video in Haiti. Int J Environ Res Public Health 13 (2).  books

McDonough E, Kamp H, Camilli A. 20156 Vibrio cholerae phosphatases required for the utilization of nucleotides and extracellular DNA as phosphate sources. Mol Microbiol. 99: 453-469.  books

Dalia AB, Seed KD, Calderwood SB, Camilli A. 2015. A globally distributed mobile genetic element inhibits natural transformation of Vibrio cholerae. Proc Natl Acad Sci USA 112: 10485-10490.  books

Greene NG, Narciso AR, Filipe SR, Camilli A. 2015. Peptidoglycan branched stem peptides contribute to Streptococcus pneumoniae virulence by inhibiting pneumolysin release. PLoS Pathog. 11: e1004996. books

Fleming E, Lazinski DW, Camilli A. 2015. Carbon catabolite repression by seryl phosphorylated HPr is essential to Streptococcus pneumoniae in carbohydrate rich environments. Mol Microbiol. 6: e00078-15. books

Shan Y, Lazinski D, Rowe S, Camilli A, Lewis K. 2015. Genetic basis of persistent tolerance to aminoglycosides in Escherichia coli. MBio 6: e00078-15. books

Mitchell SL, Ismail AM, Kenrick SA, Camilli A. 2015. The VieB auxiliary protein negatively regulates the VieSA signal transduction system in Vibrio cholerae BMC Microbiol. 15: 387. books

Shainheit MG, Valentino MD, Gilmore MS, Camilli A. 2015. Mutations in pneumococcal cpsE generated via in vitro serial passaging reveals a potential mechanism of reduced encapsulation utilized by a conjunctival isolate. J Bacteriol. 197: 1781-1791. books

Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E. 2015. Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol. 194: 1763-1775. books

Bou Ghanem EN, Clark S, Du X, Wu D, Camilli A, Leong JM, Meydani SN. 2014. The α-yocopherol form of vitamin E reverses age-associated susceptibility to Streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J. Immunol. 194: 1090-1099. books

Valentino MD, Foulston L, Sadaka A, Kos VN, Villet RA, Santa Maria J Jr, Lazinski DW, Camilli A, Walker S, Hooper DC, Gilmore MS. 2014. Genes contributing to Staphylococcus aureus fitness in abscess- and infection-related ecologies. MBio pii: e01729-14. books

Seed KD, Yen M, Shapiro BJ, Hilaire IJ, Charles RC, Teng JE, Ivers LC, Boncy J, Harris JB, Camilli A. 2014. Evolutionary consequences of intra-patient phage predation on microbial populations. ELife 3:e03497. books

Dalia AB, McDonough E, Camilli A. 2014. Multiplex genome editing by natural transformation. Proc Natl Acad Sci USA 111: 8937-8942. books

Carter R, Wolf J, van Opijnen T, Muller M, Obert C, Burnham C, Mann B, Li Y, Hayden RT, Pestina T, Persons D, Camilli A, Flynn PM, Tuomanen EI, Rosch JW. 2014. Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions. Cell Host Microbe 15: 587-599. books

Bishop AL, Patimalla B, Camilli A. 2014. Vibrio cholerae-induced inflammation in the neonatal mouse cholera model. Infect Immun. 82: 2434-2447. books

van Opijnen T, Lazinski DW, Camilli A. 2014. Genome-wide fitness and genetic interactions determined by Tn-seq, a high-throughput massively aarallel sequencing method for microorganisms. Curr Protoc Mol Biol. 106:7.16.1-7.16.24. books

McDonough E, Lazinski DW, Camilli A. 2014. Identification of in vivo regulators of the Vibrio cholerae xds gene using a high-throughput genetic selection. Mol Microbiol. 92: 302-315. books

Shainheit MG, Mulé M, Camilli A. 2014. The core promoter of the capsule operon of Streptococcus pneumoniae Is necessary for colonization and invasive disease. Infect Immun. 82: 694-705. books

Kamp HD, Patimalla-Dipali B, Lazinski DW, Wallace-Gadsden F, Camilli A. 2013. Gene fitness landscapes of Vibrio cholerae at important stages of its life cycle. PLoS Pathog. 9: e1003800. books

Gilbreath JJ, Semino-Mora C, Friedline CJ, Liu H, Bodi KL, McAvoy TJ, Francis J, Nieroda C, Sardi A, Dubois A, Lazinski DW, Camilli A, Testerman TL, Merrell DS. 2013. A core microbiome associated with the peritoneal tumors of Pseudomyxoma peritonei. Orphanet J Rare Dis. 8: 105. books

van Opijnen T, Camilli A. 2013. Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms. Nat Rev Microbiol. 11: 435-442. books

Troy EB, Lin T, Gao L, Lazinski DW, Camilli A, Norris SJ, Hu L. 2013. Understanding barriers to Borrelia burgdorferi dissemination during infection using massively parallel sequencing. Infect Immun. 81: 2347-2357. books

Dalia AB, Lazinski DW, Camilli A. 2013. Characterization of undermethylated sites in Vibrio cholerae. J Bacteriol. 195: 2389-2399. books

Seed KD, Lazinski DW, Calderwood SB, Camilli A. 2013. A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity. Nature 494: 489-491. books

Lazinski DW, Camilli A. 2013. Homopolymer tail-mediated ligation PCR: a streamlined and highly efficient method for DNA cloning and library construction. Biotechniques 54: 25-34. books

Basset A, Zhang F, Benes C, Sayeed S, Herd M, Thompson C, Golenbock DT, Camilli A, Malley R. 2012. Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein. J Biol Chem. 288: 2665-2675. books

Klein BA, Tenorio EL, Lazinski DW, Camilli A, Duncan MJ, Hu LT. 2012. Identification of essential genes of the periodontal pathogen Porphyromonas gingivalis. BMC Genomics 13: 578. books

Seed KD, Faruque SM, Mekalanos JJ, Calderwood SB, Qadri F, Camilli A. 2012. Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1. PLoS Pathog. 8: e1002917. books

Mann B, van Opijnen T, Wang J, Obert C, Wang YD, Carter R, McGoldrick DJ, Ridout G, Camilli A, Tuomanen EI, Rosch JW. 2012. Control of virulence by small RNAs in Streptococcus pneumoniae. PLoS Pathog. 8: e1002788. books

van Opijnen T, Camilli A.2012. A fine scale phenotype-genotype virulence map of a bacterial pathogen. Genome Res. 22: 2541-2551. books

Nishiyama SI, Suzuki D, Itoh Y, Suzuki K, Tajima H, Hyakutake A, Homma M, Butler-Wu SM, Camilli A, Kawagishi I. 2012. Mlp24 (McpX) of Vibrio cholerae implicated in pathogenicity functions as a chemoreceptor for multiple amino acids. Infect Immun. 80:3170-3178. books

Price KE, Greene NG, Camilli A. 2012. Export requirements of pneumolysin in Streptococcus pneumoniae. J Bacteriol. 194: 3651-3660. books

Bishop AL, Tarique AA, Patimalla B, Calderwood SB, Qadri F, Camilli A. 2012. Immunization of mice with vibrio cholerae outer-membrane vesicles protects against hyperinfectious challenge and blocks transmission. J Infect Dis. 205: 412-421. books

Seper A, Fengler VH, Roier S, Wolinski H, Kohlwein SD, Bishop AL, Camilli A, Reidl J, Schild S. 2011. Extracellular nucleases and extracellular DNA play important roles in Vibrio cholerae biofilm formation. Mol Microbiol. 82: 1015-1037. books

Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR, Shirin T, Ryan ET, Calderwood SB, Finberg RW, Qadri F, Larocque RC, Harris JB. 2011. LPLUNC1 modulates innate immune responses to Vibrio cholerae. J Infect Dis. 204: 1349-1357. books

Bradley ES, Bodi K, Ismail AM, Camilli A. 2011. A genome-wide approach to discovery of small RNAs involved in regulation of virulence in Vibrio cholerae. PLoS Pathog. 7:e1002126. books

Walsh RL, Camilli A. 2011. Streptococcus pneumoniae is dessication tolerant and infectious upon rehydration. MBio. 2(3): e00092-11. books

Liu JM, Camilli A. 2011. Discovery of bacterial sRNAs by high-throughput sequencing. Methods Mol Bio. 733: 63-79. books

Seed KD, Bodi KL, Kropinski AM, Ackermann HW, Calderwood SB, Qadri F, Camilli A. 2011. Evidence of a dominant lineage of Vibrio cholerae-specific lytic bacteriophages shed by cholera patients over a 10-year period in Dhaka, Bangladesh. MBio. 2: e00334-10. books

Bishop AL, Camilli A. 2011. Vibrio cholerae: Lessons for mucosal vaccine design. Expert Rev Vaccines 10: 79-94.  books

Opijnen T, Camilli A. 2010. Genome-wide fitness and genetic interactions determined by Tn-seq, a high-throughput massively parallel sequencing method for microorganisms. Curr Protc Microbiol. Chapter 1, Unit 1E3. books

Bishop AL, Schild S, Patimalla B, Klein B, Camilli A. 2010. Mucosal immunization with Vibrio cholerae outer membrane vesicles provides maternal protection mediated by antilipopolysaccharide antibodies that inhibit bacterial motility. Infect Immun. 78: 4402-4420. books

Pratt JT, Ismail AM, Camilli A. 2010. PhoB regulates both environmental and virulence gene expression in Vibrio cholerae. Mol Microbiol. 77: 1595-15605. books

Tamayo R, Patimalla B, Camilli A. 2010. Growth in a biofilm induces a hyperinfectious phenotype in Vibrio cholerae. Infect Immun. 78: 3560-3569. books

Liu JM, Camilli A. 2010. A broadening world of bacterial small RNAs. Curr Opin Microbiol. 13: 18-23. books

van Opijnen T, Bodi KL, Camilli A. 2009. Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms. Nat Methods 6: 767-772. books

Moisi M, Jenul C, Butler SM, New A, Tutz S, Reidl J, Klose KE, Camilli A, Schild S. 2009. A novel regulatory protein involved in motility of Vibrio cholerae. J Bacteriol. 191: 7027-7038. books

Nelson EJ, Harris JB, Morris JG Jr, Calderwood SB, Camilli A. 2009. Cholera transmission: the host, pathogen and bacteriophage dynamic.  Nat Rev Microbiol. 7:693-702. books

Pratt JT, McDonough E, Camilli A. 2009. PhoB regulates motility, biofilms, and cyclic di-GMP in Vibrio cholerae. J Bacteriol 191: 6632-6642. books

Nelson EJ, Tanudra A, Chowdhury A, Kane AV, Qadri F, Calderwood SB, Coburn J, Camilli A. 2009. High prevalence of spirochetosis in cholera patients, Bangladesh. Emerg Infect Dis. 15: 571-573. books

Bourassa L, Camilli A. 2009. Glycogen contributes to the environmental persistence and transmission of Vibrio cholerae. Mol Microbiol. 72: 124-138. books

Liu JM, Livny J, Lawrence MS, Kimball MD, Waldor MK, Camilli A. 2009. Experimental discovery of sRNAs in Vibrio cholerae by direct cloning, 5S/tRNA depletion and parallel sequencing. Nucleic Acids Res. 37: e46. books

Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ. 2009. An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. J Biol Chem. 284: 9899-9907. books

Price KE, Camilli A. 2009. Pneumolysin localizes to the cell wall of Streptococcus pneumoniae. J Bacteriol. 191: 2163-2168. books

Schild S, Nelson EJ, Bishop AL, Camilli A. 2009. Characterization of Vibrio cholerae outer membrane vesicles as a candidate vaccine for cholera. Infect Immun. 77: 472-484. books

Nelson EJ, Chowdhury A, Flynn J, Schild S, Bourassa L, Shao Y, LaRocque RC, Calderwood SB, Qadri F, Camilli A. 2008. Transmission of Vibrio cholerae is antagonized by lytic phage and entry into the aquatic environment. PLoS Pathog 4: e1000187. books

Muñoz-Elías EJ, Marcano J, Camilli A. 2008. Isolation of Streptococcus pneumoniae biofilm mutants and their characterization during nasopharyngeal colonization. Infect Immun. 76: 5049-4061. books

Song T, Mika F, Lindmark B, Liu Z, Schild S, Bishop A, Zhu J, Camilli A, Johansson J, Vogel J, Wai SN. 2008. A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles. Mol Microbiol. 70: 100-111. books

Schild S, Nelson EJ, Camilli A. 2008. Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice. Infect Immun. 76: 4554-4563. books

Martinez-Wilson HF, Tamayo R, Tischler AD, Lazinski DW, Camilli A. 2008. The Vibrio cholerae hybrid sensor kinase VieS contributes to motility and biofilm regulation by altering the cyclic diguanylate level. J. Bacteriol. 190: 6439-6447. books

LeMieux J, Woody S, Camilli A. 2008. Roles of the sortases of Streptococcus pneumoniae in assembly of the RlrA pilus. J. Bacteriol. 190: 6002-6013. books

Tamayo R, Schild S, Pratt JT, Camilli A. 2008. Role of cyclic Di-GMP during el tor biotype Vibrio cholerae infection: characterization of the in vivo-induced cyclic Di-GMP phosphodiesterase CdpA. Infect Immun. 76: 1617-1627. books

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