Recent Publications from the Bullock Lab

 

Research Publications Biochemistry Cell Biology Genetics

 

Peterson JN, Lin B, Shin J, Phelan PJ, Tsichlis P, Schwob JE, Bullock PA. 2017. The Replication of JCV DNA in the G144 oligodendrocyte cell line is dependent upon Akt. J Virol. Epub ahead of print.  books

Grubman SA, Shin J, Phelan PJ, Gong A, Can H, Dilworth R, Kini SK, Gagnon D, Archambault J, Meinke G, Bohm A, Jefferson DM, Bullock PA. 2016. Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T-antigen. Virology. 497: 92-101. books

Meinke G, Phelan PJ, Shin J, Gagnon D, Archambault J, Bohm A, Bullock PA. 2016. Structural based analyses of the JC Virus T-antigen F258L mutant provides evidence for DNA dependent conformational changes in the C-termini of polyomavirus origin binding domains. PLoS Pathog. 12: e1005362.  books

Shin J, Phelan PJ, Chhum P, Bashkenova N, Yim S, Parker R, Gagnon D, Gjoerup O, Archambault J, Bullock PA. 2014. Analysis of JC virus DNA replication using a quantitative and high-throughput assay. Virology 468-470: 113-125. books

Meinke G, Phelan PJ, Kalekar R, Shin J, Archambault J, Bohm A, Bullock PA. 2014. Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain. PLoS Pathog. 10: e1003966. books

Meinke G, Phelan PJ, Harrison C, Bullock PA. 2013. Analysis of the co-structure of the SV40 T-antigen origin binding domain with Site I reveals a correlation GAGGC spacing and spiral assembly. J Virol. 87: 2923-2934. books

Meinke G, Phelan P, Fradet-Turcotte A, Archambault J, Bullock PA. 2011. Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain. Acta Crystallogr D Biol Crystallogr. 67: 560-567. books

Harrison CJ, Meinke G, Kwun HJ, Rogalin H, Phelan PJ, Bullock PA, Chang Y, Moore PS, Bohm A. 2011. Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Biol. 409: 529-42. books

Meinke G, Bullock PA. 2011. Structural "snap-shots" of the initiation of SV40 replication. In Small DNA Tumor Viruses, K Gaston, ed, Horizon Scientific Press, Norwich, UK  books

Meinke G, Phelan PJ, Fradet-Turcotte A, Bohm A, Archambault J, Bullock PA. 2011. Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA. J Virol. 85: 818-827. books

Fradet-Turcotte A, Morin G, Lehoux M, Bullock PA, Archambault J. 2010. Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replication. Virology 399: 65-76. Abstract in PubMed

Kumar A, Joo WS, Meinke G, Moine S, Naumova EN, Bullock PA. 2008. Evidence for a structural relationship between BRCT domains and the helicase domains of the replication initiators encoded by the Polyomaviridae and Papillomaviridae families of DNA tumor viruses. J Virol. 82: 8849-8862. books

Fradet-Turcotte A, Vincent C, Joubert S, Bullock PA, Archambault J. 2007. Quantitative analysis of the binding of simian virus 40 large T antigen to DNA. J Virol. 81: 9162-974. books

Kumar A, Meinke G, Reese DK, Moine S, Phelan PJ, Fradet-Turcotte A, Archambault J, Bohm A, Bullock PA. 2007. Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA. J Virol. 81: 4808-4818. books

Meinke G, Phelan P, Moine S, Bochkareva E, Bochkarev A, Bullock PA,  Bohm A. 2007. The Crystal Structure of the SV40 T-antigen Origin Binding Domain in Complex with DNA. PLOS Biol. 5: 144-156. books

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