Recent Publications from the Brooks Lab


Research Publications Cell Biology


Cao L, Weetall M, Bombard J, Qi H, Arasu T, Lennox W, Hedrick J, Sheedy J, Risher N, Brooks PC, Trifillis P, Trotta C, Moon YC, Babiak J, Almstead NG, Colacino JM, Davis TW, Peltz SW. 2016. Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform. PLoS One. 11: e0168366. books

Caron JM, Ames JJ, Contois L, Liebes L, Friesel R, Muggia F, Vary CP, Oxburgh L, Brooks PC. 2016. Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope. Am J Pathol. 186: 1649-1661. books

Ames JJ, Henderson T, Liaw L, Brooks PC. 2016. Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model. Methods Mol Biol. 1406: 255-269. books

Ames JJ, Contois L, Caron JM, Tweedie E, Yang X, Friesel R, Vary C, Brooks PC. 2016. Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway. J Biol Chem. 291: 2731-2750. books

Contois LW, Akalu A, Caron JM, Tweedie E, Cretu A, Henderson T, Liaw L, Friesel R, Vary C, Brooks PC. 2015. Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo. Angiogenesis 18: 31-46. books

Duarte CW, Murray K, Lucas FL, Fairfield K, Miller H, Brooks P, Vary CP. 2014. Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia. Cancer Epidemiol Biomarkers Prev. 23: 117-125.  books

Favreau AJ, Vary CP, Brooks PC, Sathyanarayana P. 2014. Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia. Cancer Med. 3: 265-272.  books

Gong Y, Yang X, He Q, Gower L, Prudovsky I, Vary CP, Brooks PC, Friesel RE. 2013. Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src. Angiogenesis 16: 861-875.  books

Rosenwasser AM, Fixaris MC, Crabbe JC, Brooks PC, Ascheid S. 2013. Escalation of intake under intermittent ethanol access in diverse mouse genotypes. Addict Biol. 18:496-507. books

Contois LW, Nugent DP, Caron JM, Cretu A, Tweedie E, Akalu A, Liebes L, Friesel R, Rosen C, Vary C, Brooks PC. 2012. Insulin-like growth factor binding Protein-4 differentially inhibits growth factor-induced angiogenesis. J Biol Chem. 287: 1779-1789. books

Romero D, O'Neill C, Terzic A, Contois L, Young K, Conley BA, Bergan RC, Brooks PC, Vary CP. 2011. Endoglin regulates cancer-stromal cell interactions in prostate tumors. Cancer Res. 71: 3482-3493. books

Singh NK, Quyen DV, Kundumani-Sridharan V, Brooks PC, Rao GN. 2010. AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis. J Biol Chem. 285: 16830-16843. books

Hamilton HK, Rose AE, Christos PJ, Shapiro RL, Berman RS, Mazumdar M, Ma MW, Krich D, Liebes L, Brooks PC, Osman I. 2010. Increased shedding of HU177 correlates with worse prognosis in primary melanoma. J Transl Med. 8: 19. books

Contois L, Akalu A, Brooks PC. 2009. Integrins as "functional hubs" in the regulation of pathological angiogenesis. Semin Cancer Biol. 19: 318-328. books

Yu JZ, Warycha MA, Christos PJ, Darvishian F, Yee H, Kaminio H, Berman RS, Shapiro RL, Buckley MT, Liebes LF, Pavlick AC, Polsky D, Brooks PC, Osman I. 2008. Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients. J Transl Med. 6:70. books

Ng B, Zakrzewski J, Warycha M, Christos PJ, Bajorin DF, Shapiro RL, Berman RS, Pavlick AC, Polsky D, Mazumdar M, Montgomery A, Liebes L, Brooks PC, Osman I. 2008. Shedding of distinct cryptic collagen epitope (HU177) in sera of melanoma patients. Clin Cancer Res. 14: 6253-6258. books

Cretu A, Brooks PC. 2007. Impact of the non-cellular tumor microenvironment on metastasis: potential therapeutic and imaging opportunities. J Cell Physiol. 213: 391-402. books

Cretu A, Roth JM, Caunt M, Akalu A, Policarpio D, Formenti S, Gagne P, Liebes L, Brooks PC. 2007. Disruption of endothelial cell interactions with the novel HU177 cryptic collagen epitope inhibits angiogenesis. Clin Cancer Res. 13: 3068-3078. books

Akalu A, Roth JM, Caunt M, Policarpio D, Liebes L, Brooks PC. 2007. Inhibition of angiogenesis and tumor metastasis by targeting a matrix immobilized cryptic extracellular matrix epitope in laminin. Cancer Res. 67: 4353-4363. books

Hobeika MJ, Thompson RW, Muhs BE, Brooks PC, Gagne PJ. 2007. Matrix metalloproteinases in peripheral vascular disease. J Vasc Surg. 45: 849-857. books

Oxelmark E, Roth JM, Brooks PC, Braunstein SE, Schneider RJ, Garabedian MJ. 2006. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol. 26: 5205-5213. books

Xavier S, Macdonald S, Roth J, Caunt M, Akalu A, Morais D, Buckley MT, Liebes L, Formenti SC, Brooks PC. 2006. The vitamin-like dietary supplement para-aminobenzoic acid enhances the antitumor activity of ionizing radiation.Int J Radiat Oncol Biol Phys. 65: 517-527. books

Roth JM, Caunt M, Cretu A, Akalu A, Policarpio D, Li X, Gagne P, Formenti S, Brooks PC. 2006. Inhibition of experimental metastasis by targeting the HUIV26 cryptic epitope in collagen. Am J Pathol. 168: 1576-1586. books

Caunt M, Hu L, Tang T, Brooks PC, Ibrahim S, Karpatkin S. 2006. Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis. Cancer Res. 66: 4125-4132. books

Akalu A, Cretu A, Brooks PC. 2005. Targeting integrins for the control of tumour angiogenesis. Expert Opin Investig Drugs.14: 1475-86. books

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