Recent Publications from the Bohm Lab


Research Publications Cell Biology Pharmacology


Takemoto Y, Slough DP, Meinke G, Katnik C, Graziano ZA, Chidipi B, Reiser M, Alhadidy MM, Ramirez R, Salvador-Montañés O, Ennis S, Guerrero-Serna G, Haburcak M, Diehl C, Cuevas J, Jalife J, Bohm A, Lin YS, Noujaim SF. 2017. Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule. FASEB J. Epub ahead of print.   books

Meinke G, Karpinski J, Buchholz F, Bohm A. 2017. Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA. Nucleic Acids Res. 45: 9726-9740.   books

Schiemer J, Bohm A, Lin L, Merrill-Skoloff G, Flaumenhaft R, Huang JS, Le Breton GC, Chishti AH. 2016. Gα13 switch region 2 relieves talin autoinhibition to activate IαIbβ3 integrin. J Biol Chem. 2: pii: 10.  books

Shearer AM, Rana R, Austin K, Baleja JD, Nguyen N, Bohm A, Covic L, Kuliopulos A. 2016. Targeting liver fibrosis with a cell-penetrating PAR2 pepducin. J Biol Chem. 291: 23188-23198. books

Grubman SA, Shin J, Phelan PJ, Gong A, Can H, Dilworth R, Kini SK, Gagnon D, Archambault J, Meinke G, Bohm A, Jefferson DM, Bullock PA. 2016. Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T-antigen. Virology. 497: 92-101. books

Meinke G, Bohm A, Hauber J, Pisabarro MT, Buchholz F. 2016. Cre recombinase and other tyrosine recombinases. Chem Rev. 116: 12785-12820. books

Meinke G, Phelan PJ, Shin J, Gagnon D, Archambault J, Bohm A, Bullock PA. 2016. Structural based analyses of the JC Virus T-antigen F258L mutant provides evidence for DNA dependent conformational changes in the C-termini of polyomavirus origin binding domains. PLoS Pathog. 12: e1005362.  books

Zhang P, Leger AJ, Baleja JD, Rana R, Corlin T, Nguyen N, Koukos G, Bohm A, Covic L, Kuliopulos A. 2015. Allosteric activation of a G protein coupled receptor with cell-penetrating receptor mimetics. J Biol Chem. 290: 15785-15798. books

Srinivasan S, Romagnoli M, Bohm A, Sonenshein GE. 2014. N-Glycosylation regulates ADAM8 processing and activation. J Biol Chem. 289: 33676-33688. books

Harrison C, Jiang T, Banerjee P, Meinke G, D'Abramo CM, Schaffhausen B, Bohm A. 2013. Polyomavirus large T-antigen binds symmetrical repeats at the viral origin in an asymmetrical manner. J Virol. 87: 13751-13759. books

Foley CJ, Fanjul-Fernández M, Bohm A, Nguyen N, Agarwal A, Austin K, Koukos G, Covic L, López-Otín C, Kuliopulos A. 2013. Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis. Oncogenesis 33: 2264-2272. books

Zhang P, Gruber A, Kasuda S, Kimmelstiel C, O'Callaghan K, Cox DH, Bohm A, Baleja JD, Covic L, Kuliopulos A. 2012. Suppression of arterial thrombosis without affecting hemostatic parameters with a cell-penetrating PAR1 pepducin. Circulation 126: 83091. books

Ghazy MA, Gordon JM, Lee SD, Singh BN, Bohm A, Hampsey M, Moore C. 2012. The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site. Nucleic Acids Res. 40: 1214-1225. books

Gordon JM, Shikov S, Kuehner JN, Liriano M, Lee E, Stafford W, Poulsen MB, Harrison C, Moore C, Bohm A. 2011. Reconstitution of CF IA from overexpressed subunits reveals stoichiometry and provides insights into molecular topology. Biochemistry 50: 10203-10214. books

Sevigny LM, Zhang P, Bohm A, Lazarides K, Perides G, Covic L, Kuliopulos A. 2011. Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins. Proc Natl Acad Sci USA 108: 8491-8496. books

Ezeokonkwo C, Zhelkovsky A, Lee R, Bohm A, Moore CL. 2011. A flexible linker region in Fip1 is needed for efficient mRNA polyadenylation. RNA 17: 652-664. books

Harrison CJ, Meinke G, Kwun HJ, Rogalin H, Phelan PJ, Bullock PA, Chang Y, Moore PS, Bohm A. 2011. Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin. J Mol Biol. 409: 529-542. books

Meinke G, Phelan PJ, Fradet-Turcotte A, Bohm A, Archambault J, Bullock PA. 2011. Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA. J Virol. 85: 818-827. books

Bose K, Meinke G, Bohm A, Baleja JD. 2011. Design and characterization of an enhanced repressor of human papillomavirus E2 protein. FASEB J. 25: 2354-2361. books

Kwun HJ, Guastafierro A, Shuda M, Meinke G, Bohm A, Moore PS, Chang Y. 2009. The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication. J Virol. 83: 12118-12128. books

Balbo PB, Bohm A. 2009. Proton transfer in the mechanism of polyadenylate polymerase. Biochem J. 420: 229-238. books

Meinke G, Ezeokonkwo C, Balbo P, Stafford W, Moore C, Bohm A. 2008. Structure of yeast poly(A) polymerase in complex with a peptide from Fip1, an intrinsically-disordered protein. Biochemistry 547: 6848-6859-6869. books

Morstadt L, Bohm A, Yoksel D, Kumar K, Stollar BD, Baleja JD. 2008. Engineering and characterization of a single chain surrogate light chain variable domain. Protein Sci. 17: 458-465. books

Balbo P, Bohm A. 2007. Mechanism of poly(A) polymerase: Structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis. Structure 15: 1117-1131. books

Kumar A, Meinke G, Reese DK, Moine S, Phelan PJ, Fradet-Turcotte A, Archambault J, Bohm A, Bullock PA. 2007. Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA. J Virol. 81: 4808-4818. books

Balbo P, Toth J, Meinke G, Bohm A. 2007. X-ray crystallographic and steady state fluorescence characterization of the protein dynamics of yeast polyadenylate polymerase. J Mol Biol. 366: 1401-1415. books

Meinke G, Phelan P, Moine S, Bochkareva E, Bochkarev A, Bohm A. 2007. The crystal structure of the SV40 T-antigen origin binding domain in complex with DNA. PloS Bio. : e23. books

Reese DK, Meinke G, Kumar A, Moine S, Chen K, Sudmeier JL, Bachovchin W, Bohm A, Bullock, PA. 2006. Analysis of the transit of DNA through T-antigen hexamers provides insights into a eukaryotic helicase and the initiation of simian virus 40 DNA replication. J Virol. 80: 12248-12259. books

Swift S, Leger AJ, Talav J, Zhang L, Bohm A, Kuliopulos A. 2006. Role of the PAR1 receptor 8th helix in signaling: The 7-8-1 receptor activation mechanism. J Biol Chem. 281: 4109-4116. books

Meinke G, Bullock PA, Bohm A. 2006. Crystal structure of the SV40 large T-antigen origin-binding domain. J Virol. 80: 4304-4312. books

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