Recent Publications from the Black Lab


Research Publications Cell Biology


Quinn KP, Sullivan KE, Liu Z, Ballard Z, Siokatas C, Georgakoudi I, Black LD. 2016. Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction. Sci Rep. 6: 35823. Abstract in PubMed

Stoppel WL, Gao AE, Greaney AM, Partlow BP, Bretherton RC, Kaplan DL, Black LD 3rd. 2016. Elastic, silk-cardiac extracellular matrix hydrogels exhibit time-dependent stiffening that modulates cardiac fibroblast response. J Biomed Mater Res A 104: 3058-3072.  Abstract in PubMed

Gao AE, Sullivan KE, Black LD. 2016. Lysyl oxidase expression in cardiac fibroblasts is regulated by α2β1 integrin interactions with the cellular microenvironment. Biochim Biophys Acta. 475: 70-75   books

Sullivan KE, Burns LJ, Black LD 3rd. 2015. An in vitro model for the assessment of stem cell fate following implantation within the infarct microenvironment identifies ISL-1 expression as the strongest predictor of c-Kit+ cardiac progenitor cells' therapeutic potential. J Mol Cell Cardiol. 88: 91-100.   books

Stoppel WL, Kaplan DL, Black LD 3rd. 2015. Electrical and mechanical stimulation of cardiac cells and tissue constructs. Adv Drug Deliv Rev. pii: S0169-409X(15)00170-2.   books

Williams C, Sullivan K, Black LD 3rd. 2015. Partially digested adult cardiac extracellular matrix promotes cardiomyocyte proliferation in vitro. Adv Healthc Mater. 4: 1545-1554. books

Stoppel WL, Hu D, Domian IJ, Kaplan DL, Black LD. 2015. Anisotropic silk biomaterials containing cardiac extracellular matrix for cardiac tissue engineering. Biomed Mater. 10: 034105. books

Stoppel WL, Ghezzi CE, McNamara SL, Black III LD, Kaplan DL. 2015. Clinical applications of naturally derived biopolymer-based scaffolds for regenerative medicine. Ann Biomed Eng. 43: 657-680. books

Williams C, Budina E, Stoppel WL, Sullivan KE, Emani S, Emani SM, Black LD 3rd. 2015. Cardiac extracellular matrix-fibrin hybrid scaffolds with tunable properties for cardiovascular tissue engineering. Acta Biomater. 14: 84-89. books

Lan JY, Williams C, Levin M, Black LD 3rd. 2014. Depolarization of cellular resting membrane potential promotes neonatal cardiomyocyte proliferation in vitro. Cell Mol Bioeng. 7: 432-445. books

Gershlak JR, Black432-445. LD 3rd. 2014. β1 integrin binding Plays a role in the constant traction force generation in response to varying stiffness for Cells grown on mature cardiac extracellular matrix. Exp Cell Res. 330: 311-324. books

Morgan KY, Black LD 3rd. 2014. Creation of a bioreactor for the application of variable amplitude mechanical stimulation of fibrin gel-based engineered cardiac tissue. Methods Mol Biol. 1181: 177-187. books

Morgan KY, Black LD 3rd. 2014. Investigation into the effects of varying frequency of mechanical stimulation in a cycle-by-cycle manner on engineered cardiac construct function. J Tissue Eng Regen Med. 11: 342-353. books

Morgan KY, Black LD 3rd. 2014. It's all in the timing: Modeling isovolumic contraction through development and disease with a dynamic dual electromechanical bioreactor system. Organogenesis 10: 317-322. books

Lau JJ, Wang RM, Black LD 3rd. 2014. Development of an arbitrary waveform membrane stretcher for dynamic cell culture. Ann Biomed Eng. 42: 1062-1073. books

Morgan KY, Black LD 2014. Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs. Tissue Eng Part A 20: 1654-1657. books

Twardowski RL, Black LD 3rd. 2014. Cardiac fibroblasts support endothelial cell proliferation and sprout formation but not the development of multicellular sprouts in a fibrin gel co-culture model. Ann Biomed Eng. 42: 1074-1084. books

Williams C, Quinn KP, Georgakoudi I, Black LD 3rd. 2014. Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro. Acta Biomater. 10: 194-204. books

Sullivan KE, Black LD. 2013. The role of cardiac fibroblasts in extracellular matrix-mediated signaling during normal and pathological cardiac development. J Biomech Eng. 135: 71001. books

Gershlak JR, Resnikoff JI, Sullivan KE, Williams C, Wang RM, Black LD 3rd. 2013. Mesenchymal stem cells ability to generate traction stress in response to substrate stiffness is modulated by the changing extracellular matrix composition of the heart during development. Biochem Biophys Res Commun. 439: 161-166. books

Yuan Ye K, Sullivan KE, Black LD. 2011. Encapsulation of cardiomyocytes in a fibrin hydrogel for cardiac tissue engineering. J Vis Exp. pii: 3251. books

Ye KY, Black LD 3rd. 2011. Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction. J Cardiovasc Transl Res. 4: 575-591. books

Black LD 3rd, Meyers JD, Weinbaum JS, Shvelidze YA, Tranquillo RT. 2009. Cell-induced alignment augments twitch force in fibrin gel-based engineered myocardium via gap junction modification. Tissue Eng Part A. 15: 3099-3108. books

Ott HC, Matthiesen TS, Goh SK, Black LD, Kren SM, Netoff TI, Taylor DA. 2008. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med. 14: 213-221. books

Black LD, Allen PG, Morris SM, Stone PJ, Suki B. 2008. Mechanical and failure properties of extracellular matrix sheets as a function of structural protein composition. Biophys J. 94:1916-1929. books

Jesudason R, Black L, Majumdar A, Stone P, Suki B. 2007. Differential effects of static and cyclic stretching during elastase digestion on the mechanical properties of extracellular matrices. J Appl Physiol. 103: 803-811. books

Black LD, Brewer KK, Morris SM, Schreiber BM, Toselli P, Nugent MA, Suki B, Stone PJ. 2005. Effects of elastase on the mechanical and failure properties of engineered elastin-rich matrices. J Appl Physiol. 98: 1434-1441. books

Ito S, Ingenito EP, Brewer KK, Black LD, Parameswaran H, Lutchen KR, Suki B. Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling. J Appl Physiol. 98: 503-511. books

Dellacà RL, Black LD, Atileh H, Pedotti A, Lutchen KR. 2004. Effects of posture and bronchoconstriction on low-frequency input and transfer impedances in humans. J Appl Physiol. 97: 109-118. books

Black LD, Henderson AC, Atileh H, Israel E, Ingenito EP, Lutchen KR. 2004. Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs. J Appl Physiol. 96: 1808-1814. books

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research