Recent Publications from the Anwer Lab

 

Research Publications Pharmacology

 

Webster CR, Anwer MS. 2016. Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells. Am J Physiol Gastrointest Liver Physiol. 310: G865-G873. Abstract in PubMed

Schonhoff CM, Park SW, Webster CR, Anwer MS. 2016. p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2. Am J Physiol Gastrointest Liver Physiol. 310: G999-G1005. Abstract in PubMed

Webster CR, Johnston A, Anwer MS. 2014. Protein kinase Cδ protects against bile acid apoptosis by suppressing pro-apoptotic JNK and BIM pathways in human and rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 307: G1207-G1215. Abstract in PubMed

Park SW, Schonhoff CM, Webster CR, Anwer MS. 2014. Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. Am J Physiol Gastrointest Liver Physiol. 307: G863-G867. Abstract in PubMed

Anwer, MS. 2014.  Role of protein kinase C isoforms in bile formation and cholestasis. Hepatology 60: 1090-1097.  Abstract in PubMed

Anwer MS, Stieger B. 2013. Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters. Pflugers Arch. 466: 77-89. Abstract in PubMed

Ramasamy U, Anwer MS, Schonhoff CM. 2013. Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake.Am J Physiol Gastrointest Liver Physiol. 305: G513-G519. Abstract in PubMed

Pumphrey SA, Pizzirani S, Pirie CG, Anwer MS, Logvinenko T. 2013. Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma. Am J Vet Res. 74: 621-628. Abstract in PubMed

Schonhoff CM, Webster CR, Anwer MS. 2013. Hepatology 58: 284-292. Abstract in PubMed

Park SW, Schonhoff CM, Webster CR, Anwer MS. 2012. Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. Am J Physiol Gastrointest Liver Physiol. 303: G657-665.  Abstract in PubMed

Johnston A, Ponzetti K, Anwer MS, Webster CR. 2011. cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase. Am J Physiol Gastrointest Liver Physiol. 301: G385-400.  Abstract in PubMed

Schonhoff CM, Ramasamy U, Anwer MS. 2011. Nitric oxide-mediated inhibition of taurocholate uptake involves S-nitrosylation of NTCP. Am J Physiol Gastrointest Liver Physiol. 300: G364-G370. Abstract in PubMed

Hohenester S, Gates A, Wimmer R, Beuers U, Anwer MS, Rust C, Webster CR. Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J Hepatol. 53: 918-926. Abstract in PubMed

Schonhoff CM, Webster CR, Anwer MS. 2010. Cyclic AMP stimulates Mrp2 translocation by activating p38{alpha} MAPK in hepatic cells. Am J Physiol Gastrointest Liver Physiol. 298: G667-G674. Abstract in PubMed

Schonhoff CM, Yamazaki A, Hohenester S, Webster CR, Bouscarel B, Anwer MS. 2009. PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. Am J Physiol Gastrointest Liver Physiol. 297: G1259-G1267. Abstract in PubMed

Gates A, Hohenester S, Anwer MS, Webster CR. 2009. cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 296: G764-G774 Abstract in PubMed

Schonhoff CM, Thankey K, Webster CR, Wakabayashi Y, Wolkoff AW, Anwer MS. 2008. Rab4 facilitates cyclic adenosine monophosphate-stimulated bile acid uptake and Na+-taurocholate cotransporting polypeptide translocation. Hepatology 47: 1665-1670. Abstract in PubMed

Schonhoff CM, Gillin H, Webster CR, Anwer MS. 2008. Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. Hepatology. 47: 1309-1316. Abstract in PubMed

Sarkar S, Bananis E, Nath S, Anwer MS, Wolkoff AW, Murray JW. 2006. PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic 7: 1078-1091. Abstract in PubMed

Anwer MS, Gillin H, Mukhopadhyay S, Balasubramaniyan N, Suchy FJ, Ananthanarayanan M. 2005. Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp. J Biol Chem. 280: 33687-33692.  Abstract in PubMed

Cullen KA, McCool J, Anwer MS, Webster CR. 2004. Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol. 287: G334-G343. Abstract in PubMed

McConkey M, Gillin H, Webster CR, Anwer MS. 2004. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J Biol Chem. 279: 20882-20888. Abstract in PubMed

Anwer MS. 2004. Cellular regulation of hepatic bile acid transport in health and cholestasis. Hepatology 39: 581-590. Abstract in PubMed

Webster CR, Boria P, Usechak P, Anwer MS. 2002. S-adenosylmethionine and cAMP confer differential cytoprotection against bile acid-induced apoptosis in canine renal tubular cells and primary rat hepatocytes. Vet Ther. 3: 474-484. Abstract in PubMed

Webster CR, Usechak P, Anwer MS. 2002. cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release. Am J Physiol Gastrointest Liver Physiol. 283: G727-G738. Abstract in PubMed

Webster CR, Blanch C, Anwer MS. 2002. Role of PP2B in cAMP-induced dephosphorylation and translocation of NTCP. Am J Physiol Gastrointest Liver Physiol. 283: G44-G50. Abstract in PubMed

Apply to the Sackler School

apply

The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research