Volkhard Lindner, MD, PhD

Volkhard

Professor of Medicine

 

Education

MD, PhD, Physiology, University of Tübingen
Postdoctoral Training, University of Washington, Seattle

Location

Campus: MMCRI, Scarborough, ME
Laboratory: 20330

Contact Information

Office Phone: 207-396-8143
Lab Phone: 207-396-8174
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

We have identified the novel gene Collagen Triple Helix Repeat Containing-1 (Cthrc1) in a screen for novel genes associated with vascular injury and repair. Expression of Cthrc1 is induced in injured and remodeling blood vessels. Targeted disruption of the Cthrc1 gene in mice has identified important roles of this gene in vascular remodeling and cardiac performance. In vivo and in vitro data indicate that Cthrc1 can inhibit synthesis of fibrillar collagens type I and III via inhibition of TGF-β. Currently the major research efforts in the laboratory are focused on the characterization of the biochemistry and biology of Cthrc1, as well as the evaluation of Chtrc1 as a therapeutic target.

 

Lab Members

Grazina Armie Mangoba, Technology Manager Send an e-mail  Lab Research Page
Qiaozeng Wang, Research Assistant Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research