Volkhard Lindner, MD, PhD

Volkhard

Professor of Medicine

 

Education

MD, PhD, Physiology, University of Tübingen
Postdoctoral Training, University of Washington, Seattle

Location

Campus: MMCRI, Scarborough, ME
Laboratory: 20330

Contact Information

Office Phone: 207-396-8143
Lab Phone: 207-396-8174
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

We have discovered the gene Collagen Triple Helix Repeat Containing-1 (Cthrc1) in a screen for novel genes associated with vascular injury and repair and recently found that it functions as a hormone regulating metabolism and inflammatory responses. CTHRC1 blood levels are below detection in 70% of healthy human subjects, whereas levels >75ng/ml are observed in some people. Our laboratory is interested in i) determining the functions of CTHRC1 induced as a result of tissue injury, ii) the functions of circulating CTHRC1 originating from brain and bone, and iii) defining the factors and stimuli that determine circulating CTHRC1 levels and their consequences for inflammatory conditions and metabolism. Mouse genetic models for Cthrc1 gain-of-function and loss-of-function, as well as unique antibody tools have been developed by the lab to determine the mechanism of action for CTHRC1.

 

Lab Members

Mayasah Al Hashimi, Research Technologist Send an e-mail Lab Research Page
Yong-Ri Jin, Staff Scientist Send an e-mail Lab Research Page
Grazina Armie Mangoba, Technology Manager Send an e-mail  Lab Research Page
Qiaozeng Wang, Research Assistant Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development