Thomas Gridley, PhD

Professor of Medicine



BS, Biology, State University of New York - Stony Brook
PhD, Biology, Massachusetts Institute of Technology
Postdoctoral Training, Whitehead Institute


Campus: MMCRI, Scarborough, ME
Office: 2605
Laboratory: 2615

Contact Information

Office Phone: 207-396-8113

E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology


Research Synopsis

I maintain an active laboratory but no longer accept students for dissertation research. I am willing to serve as a co-mentor for thesis students and I participate in teaching and other graduate program activities.

My laboratory studies genes important for embryonic development of mice, and the connections between mutations in these genes and congenital and acquired human disease. Our analyses focus on the Notch pathway, an evolutionarily conserved intercellular signaling system, and on genes of the Snail superfamily, which encode transcriptional repressor proteins. We have created and analyzed numerous genetically engineered mouse models to understand the essential functions of individual components of these pathways, and have generated models for inherited human disease syndromes such as Alagille syndrome. We are particularly interested in the role these pathways play during cardiovascular development, physiology and disease.


Lab Members

Christine Norton, Scientific Manager  Send an e-mail

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research