Theoharis Theoharides, MD, PhD


Professor of Immunology



BA, Biology & History of Medicine, Yale University
MS, MPhil, Immunology, Yale University
PhD, Pharmacology, Yale University
MD, Yale University


Campus: Boston
Office: Jaharis 304F
Laboratory: Jaharis 304

Contact Information

Office Phone: 617-636-6866
Lab Phone: 617-636-6898
E-mail   Send an e-mail


Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology, Pharmacology


Research Synopsis

Our laboratory investigates the mechanism of selective secretion of cytokines and other pro-inflammatory molecules from mast cells. We have shown for the first time that mast cells can be activated by corticotropin-releasing hormone (CRH), the first molecule generated under stress, and by interleukin-1. CRH-activated mast cells lead to disruption of the gut-blood-brain barriers and thus contribute to brain inflammation. This process may participate in the pathophysiology of many diseases that worsen or precipitate under stress.


Lab Members

Mona Bawazeer, PhD Student in Pharmacology & Experimental Therapeutics Send an e-mail  Lab Research Page
Amanda Gross, PhD Student in Pharmacology & Experimental Therapeutics  Send an e-mail  Lab Research Page
Eirini Tsilioni, Postdoctoral Scholar Send an e-mail

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research