Shruti Sharma, PhD


Assistant Professor of Immunology



BSc, Microbiology & Biotechnology, R Ruia College
MSc, Biotechnology, University of Mumbai
PhD, Cell Biology & Immunology, University of Maryland - College Park
Postdoctoral Training, University of Massachusetts Medical School


Campus: Boston
Office: Jaharis 813
Laboratory: Jaharis 501

Contact Information

Office Phone: 617-636-0470
Lab Phone: 617-636-6612
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications Abstract in PubMed

Graduate Programs



Research Synopsis

My lab focuses on the innate immune response to nucleic acids from microbial sources as well as from ourselves. Specifically, we are evaluating the role of pathways that sense nucleic acids to shape host metabolism, tissue remodeling, fibrosis and wound healing responses. A particular focus of the lab is to understand the contribution of intracellular DNA sensing to immune-homeostasis. Using a combination of hypothesis driven and unbiased next gen approaches we hope to clarify the signaling nodes engaged during homeostasis. The physiological impact of the pathways we discover will be tested in models of inflammation including infections, autoimmunity, aging and neurodegenerative diseases. These studies will directly impact our understanding of resolution of inflammation in all settings.

A post-doc position is available in the Sharma lab to study the impact of innate immune sensing of nucleic acids on maintaining the epigenetic states of inflammation. We are interested in understanding the mechanisms controlling gene expression and specific gene expression patterns following sensing of DNA and RNA. Models of disease that we specifically focus on are multi-system chronic inflammatory models. If you are interested in investigating novel gene expression programs during innate immune responses and have some training in Bioinformatics please email your CV to me.


Lab Members

Ronald Brown, Research Technician  Send an e-mail
Jacob Hopkins, PhD Student in Immunology  Send an e-mail Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development