Sergei Mirkin, PhD


White Family Professor of Biology



MS, Genetics, Moscow State University
PhD, Molecular Biology, Institute of Molecular Genetics, Moscow
Postdoctoral Training, Institute of Molecular Genetics, Moscow


Campus: Medford
Laboratory: 200 Boston Ave, Ste 4742

Contact Information

Office Phone: 617-627-4794
Laboratory Phone: 617-627-4828
E-mail   Send an e-mail


Research Website: Lab Research Page
Recent Publications:  Abstract in PubMed

Graduate Programs



Research Synopsis

I study the mechanisms responsible for the instability of DNA repeats in various genomes. I am particularly interested in the mechanisms of expansions of triplet DNA repeats that cause numerous hereditary disorders in humans, including Fragile X mental retardation, Huntington's disease, myotonic dystrophy, and Friedreich's ataxia. My lab was the first to show that expansions could be due to the ability of these repeats to trick DNA replication into lengthening them. We are substantiating the replication model for repeat expansions in several experimental systems.


Lab Members

Jorge Cebrian Castillo, Postdoctoral Scholar Send an e-mail
Artem Kononenko, Research Associate  Send an e-mail 
Ryan McGinty, PhD Student in Biology Send an e-mail Lab Research Page
Alexandra Khristich, PhD Student in Biology Send an e-mail 
Alex Neil, MD, PhD Student in Genetics Send an e-mail  Lab Research Page
Elina Radchenko, Postdoctoral Scholar Send an e-mail 
Ekaterina Spivakovsky-Gonzalez, PhD Student in Biology Send an e-mail

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research