Ronald Lechan, MD, PhD

Ronald Lechan, MD, PhD

Professor of Medicine

 

Education

BA, Biology, Brandeis University
MD, University of Vermont
PhD, Cell, Molecular & Developmental Biology, Sackler School Tufts University 

 

Location

Campus: Boston
Office: Tupper, 4th Floor
Laboratory: Tupper, 4th Floor

Contact Information

Office Phone: 617-636-8517
Lab Phone: 617-636-8514
E-mail   Send an e-mail

 

Graduate Programs

Neuroscience

  

Research Synopsis

The anatomy and physiology of thyrotropin-releasing hormone (TRH) synthesizing neurons in the hypothalamic paraventricular nucleus (PVN) is the focus of our research. We study 1) the choroid plexis and cerebral spinal fluid in the transport of T4 into the brain; 2) type 2 deiodinase in ependymal cells (tanycytes) on feedback inhibition of thyroid hormone on hypophysiotropic TRH neurons in the PVN; 3) leptin-mediated paradoxic reduction in the biosynthesis of TRH in the PVN during fasting; and 4) the anatomical characterization, nuclear/cytoplasmic distribution, and potential interaction of thyroid hormone receptors in thyroid hormone responsive and unresponsive TRH neurons in the brain and their response to hormonal manipulation.

 

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research