Rachel Buchsbaum, MD

Rachel Buchsbaum, MD

Associate Professor of Medicine



AB, Chemistry & Physics, Harvard University
MD, Cornell University Medical College
Postdoctoral Training, Tufts University School of Medicine


Campus: Boston
Office: 75 Kneeland, 12th Floor
Laboratory: 75 Kneeland, 12th Floor

Contact Information

Office Phone: 617-636-5147
Lab Phone: 617-636-9554
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed  

Graduate Programs



Research Synopsis

My laboratory focuses on studying signal transduction pathways underlying cancer cell growth and metastasis. In particular, we are interested in pathways involving the Rac protein, a member of the Ras superfamily that is a central player in multiple signaling pathways affecting malignant cell behavior. We have found that Rac signaling can be directed through a network of distinct pathways, involving cell survival and apoptosis, cell cycling and growth, and migration and invasion, by a major regulator protein, Tiam1. A major interest is the regulation of this Tiam1/Rac signaling network in normal and malignant cells. We are also exploring the role of this network in governing interactions between tumor cells and their microenvironment.


Lab Members

Kun Xu, Postdoctoral Scholar Send an e-mail  Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research