Philip Tsichlis, MD

Philip Tsichlis, MD

Jane F Desforges Professor of Medicine

 

Education

MD, University of Athens School of Medicine
Postdoctoral Training, Tufts University School of Medicine

Location

Campus: Boston
Office: 75 Kneeland, 12th Floor
Laboratory: 75 Kneeland, 12th Floor

Contact Information

Office Phone: 617-636-6111
Lab Phone: 617-636-6153
E-mail   Send an e-mail

Links

Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology, Genetics, Immunology

 

Research Synopsis

My laboratory uses insertional mutagenesis and other genetic strategies to identify genes that are involved in oncogenesis, or regulate phenotypic changes in tumor cells. Genes identified via these strategies are used as probes to explore function from the molecular to the animal level. Some of the genes we have identified and exploited to date include Akt1, Tpl2, Gfi-1 and Gfi-1B. Our work highlights the value of genetic studies in animal models for understanding the molecular basis of cancer and other diseases in humans. Today, we use genome-wide insertional mutagenesis screens, in genetically modified animals to identify genes whose oncogenic potential is realized in the context of defined genetic settings. In addition, we use molecular strategies and animal models based on genes identified via our earlier genetic screens, to explore the role of signaling networks in the biology of cancer and in the biology of the immune system.

 

Lab Members

Elia Aguado Fraile, Postdoctoral Scholar Send an e-mail
Antonis Skliris, Postdoctoral Scholar Send an e-mail
Vasiliki Taraslia, Research Assistant Send an e-mail

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research