Peter Brooks, PhD

Peter

Professor of Medicine

 

Education

BS, University of Maine, Orono
PhD, Cellular & Developmental Biology, SUNY Stony Brook
Postdoctoral Training, Scripps Institute

Location

Campus: MMCRI, Scarborough, ME
Laboratory: 20237 & 20238

Contact Information

Office Phone: 207-396-8239
Lab Phone: 207-396-8125
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

Our laboratory is primarily interested in studying how triggering "biomechanical ECM switches" within the stromal microenvironment governs angiogenesis, inflammation and tumor progression. We study the cellular and molecular mechanisms by which integrin receptors and proteolytic enzymes trigger unique biomechanical ECM switches that result in the exposure of cryptic ECM epitopes that modulate stromal and tumor cell behavior. We are especially interested in understanding how integrin receptor binding to these control sites regulates signaling pathways that contribute to these processes. Surprisingly, inhibition of cellular interactions with one of these cryptic ECM control elements significantly alters expression of insulin-like growth factor binding protein-4 (IGFBP-4) as well as the endogenous angiogenesis inhibitor TSP-1. Establishing a more in depth molecular understanding of the diverse functions of biomechanical ECM switches in vivo may contribute to the development of unique clinical strategies for imaging and control of tumor progression.

Lab Members

Jennifer Caron, Senior Research Technician Send an e-mail   Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research