Mitch McVey, PhD

Mitch McVey, PhD

Professor of Biology



BA, Biochemistry, University of Colorado, Boulder
PhD, Molecular Biology, MIT
Postdoctoral Training, University of North Carolina, Chapel Hill


Campus: Medford
Office: 200 Boston Avenue
Laboratory: 200 Boston Avenue, Ste4741

Contact Information

Office Phone: 617-627-4196
Lab Phone: 617-627-0306
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs



Research Synopsis

Why do cells sometimes choose to repair DNA damage using strategies that result in changes to the genetic sequence? This is the central question that drives our lab’s research. We use Drosophila melanogaster as a model organism to investigate how different DNA repair and DNA damage tolerance proteins are utilized to both maintain genome stability and generate genetic diversity. Specifically, we are interested in how various DNA lesions, such as base modifications, double-strand breaks, and interstrand crosslinks, are recognized and repaired in various tissues and developmental stages of the animal. A current focus of the lab is the characterization of an error-prone, alternative end-joining pathway that utilizes a multifunctional protein named DNA polymerase theta to fix double-strand breaks. We are also applying tissue- and developmental stage-specific methods to induce DNA damage and to study how cellular context affects replication and repair of the damaged DNA.


Lab Members

Sarah Dykstra, Postdoctoral Scholar Send an e-mail Lab Research Page
Terrence Hanscom, PhD Student in Biology Send an e-mail 
Varandt Khodaverdian, PhD Student in Biology Send an e-mail Lab Research Page
Ece Kocak, Research Technician Send an e-mail 
Alice Miller, Senior Research Technician Send an e-mail Lab Research Page
Taylor Sands-Marcinkowski, PhD Student in Biology Send an e-mail 

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research