Michael Forgac, PhD

Michael Forgac, PhD

Professor of Developmental, Molecular & Chemical Biology

 

Education

BS, Biology & Chemistry, California Institute of Technology
PhD, Biochemistry & Molecular Biology, Harvard University
Postdoctoral Training, Harvard University

Location

Campus: Boston
Office: M&V 719
Laboratory: M&V 719

Contact Information

Office Phone: 617-636-6939
Lab Phone: 617-636-6922
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

Our laboratory is focused on understanding the regulation and function of the vacuolar ATPases (V-ATPases) in normal and disease processes. The V-ATPases are a family of ATP-driven proton pumps which function in such processes as intracellular membrane traffic, bone resorption and renal acidification, as well as in many disease processes, including viral infection, bone disease and cancer. Our laboratory is employing a variety of biochemical, genetic and cell biological approaches to understand how assembly of the V-ATPases is regulated in mammalian cells and the role that V-ATPases play in nutrient sensing and energy homeostasis. In particular, we are interested in their role in controlling two central regulators of cell growth and metabolism, namely AMPK and mTOR. We are also investigating the role of V-ATPases in tumor cell invasion and survival using both in vitro cell culture models and in vivo mouse models, with the ultimate aim of developing therapeutic agents to inhibit tumor growth and metastasis.

 

Lab Members

Michael Collins, PhD Student in Cell, Molecular & Developmental Biology Send an e-mail  Lab Research Page
Christina McGuire, PhD Student in Biochemistry Send an e-mail Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research