Michael Forgac, PhD

Michael Forgac, PhD

Professor of Developmental, Molecular & Chemical Biology



BS, Biology & Chemistry, California Institute of Technology
PhD, Biochemistry & Molecular Biology, Harvard University
Postdoctoral Training, Harvard University


Campus: Boston
Office: M&V 719
Laboratory: M&V 719

Contact Information

Office Phone: 617-636-6939
Lab Phone: 617-636-6922
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Biochemistry, Cell, Molecular & Developmental Biology, Cellular & Molecular Physiology


Research Synopsis

Our laboratory is focused on understanding the structure and regulation of the vacuolar ATPases (V-ATPases) and their role in human disease. The V-ATPases are a family of ATP-driven proton pumps which function in both normal physiological processes, such as intracellular membrane traffic, bone resorption and renal acidification, as well as in disease processes, such as viral infection, bone disease and cancer. Our laboratory is employing a variety of biochemical, genetic and cell biological approaches in both yeast and mammalian systems to probe the structure and regulation of the V-ATPases. We are particularly interested in control of V-ATPase activity through reversible dissociation of the complex. We have also begun to address the role of V-ATPases in tumor cell invasion and to develop genetic screens to identify isoform-specific inhibitors of the V-ATPase that would be useful therapeutic agents in treating tumor metastasis and osteoporosis.


Lab Members

Michael Collins, PhD Student in Cell, Molecular & Developmental Biology Send an e-mail  Lab Research Page
Christina McGuire, PhD Student in Biochemistry Send an e-mail Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research