Malavika Raman, PhD

Mali

Assistant Professor of Developmental, Molecular and Chemical Biology

 

Education


BPharm, MS, Birla Institute of Technology and Science, India
PhD, University of Texas Southwestern Medical Center
Postdoctoral Training, Harvard Medical School

Location

Campus: Boston
Office: Jaharis 6
Laboratory: Jaharis 6

Contact Information

Office Phone: 617-636-6690
Email Send an e-mail

 

Links

Research Website  Lab Research Page
Recent Publications Abstract in PubMed

 

Graduate Programs

Cell, Molecular & Developmental Biology, Neuroscience

 

Research Synopsis

Our group is interested in understanding mechanisms that maintain protein homeostasis within the cell. In particular we are interested in the role of the VCP AAA-ATPase in the recognition and degradation of ubiquitin-modified substrates. VCP is an abundant cellular chaperone that performs critical functions in diverse cellular programs such as ER associated degradation, autophagy, DNA damage responses and chromatin re-modeling. Importantly, VCP mutations are known to cause a spectrum of neurodegenerative disorders and its over-expression is prevalent in many cancers. Our recent proteomic profiling of VCP complexes demonstrates that VCP is targeted to diverse cellular structures and organelles via distinct adaptor proteins. We are interested in identifying new pathways that utilize VCP activity, determine its mechanism of action on substrates and identify new VCP targets. Our goal is to apply these findings to help understand its dysfunction in human disorders.

Lab Members

Rakesh Ganji, Postdoctoral Scholar Send an e-mail Lab Research Page
Sirisha Mukkavalli, Postdoctoral Scholar  Lab Research Page
Flavio Somanji, Research Technician  Send an e-mail Lab Research Page

 

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research