Linden Hu, MD

Linden Hu, MD

Professor of Molecular Biology & Microbiology



AB, Human Biology, Brown University
MD, Brown University


Campus: Boston
Office: South Cove 802
Laboratory: South Cove 8

Contact Information

Office Phone: 617-636-8498
Lab Phone: 617-636-7613
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Immunology, Molecular Microbiology


Research Synopsis

Our laboratory studies host-pathogen interactions of the organisms Borrelia burgdorferi and Porphyromonas gingivalis. For B. burgdorferi, the causative agent of Lyme disease, the laboratory is interested in both how the organism responds and adapts to its changing environments, as well as the impact of the host immune response on manifestations of disease. There are currently several major areas of research in the laboratory focused on B. burgdorferi. The projects are: 1) understanding the mechanisms by which the organism escapes innate and adaptive immunity to establish long-term infection; 2) discovering the components of intracellular control of innate immune responses to infection with B. burgdorferi and how innate immune tolerance by the host contributes to bacterial persistence; 3) strategies for reducing the carriage of B. burgdorferi in its wild-life reservoirs as a strategy for decreasing human disease; 4) development of novel human vaccines. For our work on P. gingivalis, the laboratory is interested in understanding how different members of the oral microbial community and probiotic bacteria can interact with P. gingivalis to mitigate its role in periodontitis.


Lab Members

Morgen Clark, Research Technician Send an e-mail 
Marisha Collins, Postdoctoral Scholar Send an e-mail  Lab Research Page
Louis Cornacchione, PhD Student in Molecular Microbiology  Send an e-mail  Lab Research Page
Joshua Norville, Research Coordinator Send an e-mail 
Tanja Petnicki-Ocwieja, Assistant Professor Send an e-mail  Lab Research Page
James Phelan, PhD Student in Molecular Microbiology - MERGE-ID Send an e-mail  Lab Research Page
Urmila Powale, PhD Student in Immunology  Send an e-mail  Lab Research Page
Meghan Ramsey, Postdoctoral Scholar Send an e-mail Lab Research Page
Bijaya Sharma, Postdoctoral Scholar Send an e-mail Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development