Larry Feig, PhD

Larry Feig, PhD

Professor of Developmental, Molecular & Chemical Biology

 

Education

BS, Chemical Engineering, Columbia University
MS, Chemical Engineering, MIT
PhD, Physiology, Harvard University
Postdoctoral Training, Dana Farber Cancer Institute

Location

Campus: Boston
Office: Jaharis 605
Laboratory: Jaharis 601

Contact Information

Office Phone: 617-636-6956
Lab Phone: 617-636-6955
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology, Neuroscience

 

Research Synopsis

My lab focuses on two related projects revealing the molecular mechanisms controlling the sex-dependent effects of stress across generations: The first investigates how the neuronal, calcium-sensitive activator of Ras, Ras-GRF1, regulates the HPA axis response to acute and chronic stress specifically in adolescent females. The second investigates a newly detected form of epigenetic inheritance that occurs in males exposed to social instability stress during adolescence. These mice transmit anxiety and sociability defects specifically to their female offspring across at least 3 generations. At present, we are investigating how sperm miRNAs function as mediators of this Lamarckian type of inheritance in mice, and whether a similar phenomenon occurs in men raised in abusive and/or dysfunctional families.

 

Lab Members

Shan-Xue Jin, Research Associate Send an e-mail  Lab Research Page
David Dickson, MD, PhD Student in Neuroscience  Send an e-mail Lab Research Page
Virginia Mensah, Research Fellow Send an e-mail Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research