John Leong, MD, PhD

John

Professor of Molecular Biology & Microbiology

 

Education

BA, Biology, Brown University
MD, PhD, Molecular Biology, Brown University
Postdoctoral Training, Tufts University School of Medicine

Location

Campus: Boston
Office: Arnold 511E
Laboratory: Arnold 511

Contact Information

Office Phone: 617-636-0488
Lab Phone: 617-636-0906
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Immunology, Molecular Microbiology

 

Research Synopsis

In causing disease, bacterial pathogens establish an infectious niche and generate damage within the mammalian host. We investigate three bacterial pathogens to understand the host-microbe interactions that promote colonization and disease, and then, during resolution of infection, mediate microbial clearance. Enterohemorrhagic Escherichia coli O157:H7 is a food-borne intestinal pathogen that that injects into intestinal epithelial cells proteins that stimulate actin polymerization directly beneath bound bacteria. We are studying the action of these proteins to understand how interactions between these bacteria and the intestinal epithelium promote colonization and disease, as well as to gain insight into fundamental mechanisms of actin assembly in mammalian cells. Streptococcus pneumoniae, an important cause of lung infection, and pathogenic spirochetes, such as the Lyme disease spirochete Borreliae burgdorferi, each can establish a localized infection but are also capable of spreading throughout the host. We investigate the microbe-host cell interactions that promote tissue invasion and systemic spread, as well as the components of the host immune response that contribute to immune protection and bacterial clearance.

 

Lab Members

Sowmya Balasubramanian, Postdoctoral Scholar Send an e-mail  Lab Research Page
Rudra Bhowmick, Postdoctoral Scholar Send an e-mail  Lab Research Page
Elsa Bou Ghanem, Postdoctoral Scholar Send an e-mail  Lab Research Page
Stacie Clark, Research Assistant Send an e-mail
Laurice Jackson, MERGE-ID PhD Student in Molecular Microbiology Send an e-mail  Lab Research Page
Dakshina Jandhyala, Research Associate Send an e-mail
Yi-Pin Lin, Postdoctoral Scholar Send an e-mail  Lab Research Page
Loranne Magoun, Laboratory Manager Send an e-mail  Lab Research Page
Marcia Osburne, Senior Research Associate Send an e-mail Lab Research Page
Michael Pereira, PhD Student in Molecular Microbiology Send an e-mail  Lab Research Page
Sara Roggensack, PhD Student in Molecular Microbiology Send an e-mail  Lab Research Page

Application for 2015 Admission

The application for 2015 admissions will be available soon.