John Castellot, PhD


Professor of Integrative Physiology & Pathobiology



BS, Chemistry & Biology, George Washington University
PhD, Pharmacology, Harvard University
Postdoctoral Training, Harvard Medical School


Campus: Boston
Office: M&V 515
Laboratory: M&V 515 & 516

Contact Information

Office Phone: 617-636-0303
Lab Phone: 617-636-6608
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology, Pharmacology & Experimental Therapeutics 


Research Synopsis

Excessive proliferation of smooth muscle cells is the hallmark of many diseases, including atherosclerosis, restenosis following vascular surgery, hypertension, fibroids, asthma, and several congenital defects. We recently discovered a protein, CCN5, that inhibits smooth muscle cell proliferation. We are exploring the mechanism of action of CCN5 in cell culture systems, and have generated "proof-of-concept" data in animal models for restenosis, fibroids, and asthma suggesting that gene or protein therapy using CCN5 may be a useful therapeutic approach.


Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research