Professor of Ophthalmology
BS, Chemistry & Physics, University of Pittsburgh
ScM, Epidemiology, Harvard School of Public Health
MD, University of Pittsburgh School of Medicine
Office Phone: 617-636-9000
Clinical & Translational Science
My research interests include the etiology, prevention and treatment of macular degeneration, hereditary retinal disorders, retinal vascular disorders, and degenerative disorders. Our research team studies the effect of lifestyle and genetic and biochemical biomarkers for age-related and younger onset macular degenerations as well as macular dystrophies. I have found that the dietary antioxidants lutein and zeaxanthin as well as fat intake, omega-3 fatty acids, and obesity influence the risk of macular degeneration and progression to the advanced stages. We discovered 15 different genetic variants including some rare and highly penetrant genetic variants which are strongly associated with the macular degeneration in families. We developed comprehensive risk prediction models and an on-line risk calculator. Current work is focused on identifying genetic associations and interactions with non-genetic risk factors and sub-phenotypes of the disease.