Joan Mecsas, PhD


Professor of Molecular Biology & Microbiology



BA, Biochemistry, Swarthmore College
PhD, Cellular & Molecular Biology, University of Wisconsin, Madison
Postdoctoral Training, Stanford University


Campus: Boston
Office: South Cove 803
Laboratory: South Cove 8

Contact Information

Office Phone: 617-636-2742
Lab Phone: 617-636-7613
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Immunology, Molecular Microbiology


Research Synopsis

Yersinia pseudotuberculosis is an enteric pathogen that causes gastroenteritis, mesentric adenitis and occasionally spreads systemically. In order for the bacteria to cause disease and be transmitted to another host, they must survive in the gastrointestinal tract. We study the bacterial genes necessary for survival within the small intestine. We have found that one or more of the Yops, proteins that are secreted by Yersinia and translocated into host cells where they alter the function of mammalian cells, are required for Yersinia to grow in the small intestine. We are determining which Yops are required and the cells they target in the small intestine.


Lab Members

Alyssa Fasciano, PhD Student in Immunology Send an e-mail Lab Research Page
Charmaine Nganje, PREP Scholar Send an e-mail  Lab Research Page
Giang Nguyen, MERGE-ID PhD Student in Immunology Send an e-mail  Lab Research Page
Ruby Pina-Mimbela, Senior Research Technician Send an e-mail Lab Research Page
Lamyaa Shaban, MERGE ID PhD Student in Molecular Microbiology Send an e-mail  Lab Research Page
Rebecca Silver, PhD Student in Immunology Send an e-mail Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research