Jennifer Trowbridge, PhD

Assistant Professor of Medicine

 

Education

BSc, Genetics, University of Western Ontario
PhD, Microbiology & Immunology, University of Western Ontario
Postdoctoral Training, Dana Farber Cancer Institute, Boston

 

Location

Campus: The Jackson Laboratory, Bar Harbor, ME
Office:  ERB 2530
Laboratory: ERB 2556

Contact Information

Office Phone: 207-288-6183
Lab Phone: 207-288-1554
E-mail   Send an e-mail 

 

Graduate Programs

Genetics

 

Research Synopsis

Hematopoietic stem cells (HSCs) serve as the backbone of the hematopoietic system, undergoing self-renewal and differentiation to generate the cells of all of the blood lineages. In several types of blood cancers, leukemia stem cells (LSCs) with analogous properties that underlie the expansion of malignant cells have been defined. We seek to answer two central questions pertaining to the epigenetic regulation of the self-renewal process within these cell types. One, are the epigenetic mechanisms responsible for regulating self-renewal common or distinct in HSCs and LSCs? Two, are epigenetic patterns within HSCs or LSCs programmed in response to cues from the bone marrow microenvironment? By identifying key differences in the epigenetic mechanisms underlying the regulation of HSCs and LSCs, we seek to reveal novel strategies for directed leukemia therapy.

 

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research