Jeffrey K Marchant, PhD


Research Assistant Professor of Integrative Physiology & Pathobiology



BS, Biology, St Lawrence University
MS, Plant Biology, Indiana University
PhD, Cell, Molecular & Developmental Biology, Sackler School, Tufts University
Postdoctoral Training, University of Rochester, Tufts University School of Medicine


Campus: Boston
Office: M&V 522A
Laboratory: M&V 522

Contact Information

Office Phone: 617-636-6699
Lab Phone: 617-636-6699
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology


Research Synopsis

Our major research interests focus on the eye with emphasis on the aqueous humor outflow pathway and its role in intraocular pressure (IOP) regulation and glaucoma. Elevated IOP is a major risk factor for the development of glaucoma and all existing glaucoma therapies aim to lower IOP. Despite the importance of IOP, the molecular mechanisms of aqueous humor outflow and their abnormalities in glaucoma are very poorly understood. Through the use of high-resolution 4 pi microscopy, we have discovered a novel cellular and molecular architecture at the inner wall of Schlemm's canal, the location thought to be critical for IOP regulation. The previously unappreciated intricacy of this region may provide a well-documented but unaccounted for mechanism of resistance to aqueous humor drainage and provide new targets for drug development.

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research