Jamie Maguire, PhD

Jaime

Assistant Professor of Neuroscience

 

Education

BA, BS, Art History & Neuroscience
PhD, Neuroscience, George Washington University
Postdoctoral Training, University of California, Los Angeles

Location

Campus: Boston
Office: South Cove 205
Laboratory: South Cove 201

Contact Information

Office Phone: 617-636-3595
Lab Phone: 617-636-3815
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Neuroscience, Pharmacology & Experimental Therapeutics

 

Research Synopsis

Research in my lab focuses on the regulation of GABAA receptors (GABAARs), which mediate the majority of inhibitory synaptic transmission in the central nervous system. Our goal is to understand how GABAARs and therefore GABAergic inhibition, is regulation under both physiological and pathological conditions. We use a wide variety of approaches, ranging from electrophysiology to behavior. A particular focus of the lab is the GABAergic regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which mediates the body's response to stress. Stress is a common trigger for many disorders, probably due to the impact of stress hormones on neuronal excitabilility. The major output of the stress response, neurons in the paraventricular nucleus (PVN) of the hypothalamus, are under GABAergic control. Our goal is to determine the nature of GABAAR regulation of the PVN and to understand how dysfunction affects the pathophysiology of neurologicial and neuropsychiatric disorders.

 

Lab Members

Andrew Hooper, PhD Student in Neuroscience Send an e-mail  Lab Research Page
Vallent Lee, MD, PhD Student in Neuroscience Send an e-mail  Lab Research Page
Georgina MacKenzie, Postdoctoral Scholar Send an e-mail  Lab Research Page
Laverne Melon, Postdoctoral Scholar Send an e-mail  Lab Research Page
Kate O'Toole, Postdoctoral Scholar Send an e-mail  Lab Research Page

Application for 2014 Admission

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