Jamie Maguire, PhD

Jaime

Assistant Professor of Neuroscience

 

Education

BA, BS, Art History & Neuroscience, University of Pittsburgh
PhD, Neuroscience, George Washington University
Postdoctoral Training, University of California, Los Angeles

Location

Campus: Boston
Office: South Cove 205
Laboratory: South Cove 201

Contact Information

Office Phone: 617-636-3595
Lab Phone: 617-636-3815
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Neuroscience, Pharmacology

 

Research Synopsis

Research in the Maguire lab focuses on the role of GABAA receptors (GABAARs), which mediate the majority of inhibitory synaptic transmission in the brain, in the regulation of stress-relevant circuits. Our goal is to understand how GABAARs and therefore GABAergic inhibition is regulated under both physiological and pathological conditions. Our research program investigates dysregulation in the GABAergic control of corticotropin-releasing hormone (CRH) neurons, which regulate the body’s physiological response to stress via the hypothalamic-pituitary-adrenal (HPA) axis, as a potential mechanism contributing to epilepsy and affective disorders, including postpartum depression. Our research program also investigates the role of GABAergic interneurons in the amygdala in mediating the network communication of fear and anxiety, researching the contribution to the anxiolytic effects of alcohol and co-morbid anxiety and epilepsy. The role of neurosteroid-sensitive GABAARs in these stress circuits are of particular interest to our laboratory, given that they are sensitive to regulation by ovarian and stress hormones. Overall, the Maguire lab focuses on the intersection between GABAergic inhibition and stress in neurological and neuropsychiatric disorders.

 

Lab Members

Aishwarya Kulkarni, MS Student in Pharmacology & Drug Development Send an e-mail Lab Research Page
Laverne Melon, Postdoctoral Scholar Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research