Igor Prudovsky, PhD

Igor

Associate Professor of Medicine

 

Education

MS, Cellular Biology, Moscow University
PhD, Cell & Molecular Biology, Englehardt Institute of Molecular Biology
Dr Biol Sci, Englehardt Institute of Molecular Biology
Postdoctoral Training, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Location

Campus: MMCRI, Scarborough, ME
Office: 20357
Laboratory: 20341 & 20342

Contact Information

Office Phone: 207-396-8146
Lab Phone: 207-396-8165
E-mail   Send an e-mail

Links

Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

While most extracellular proteins have a signal peptide required for their export through endoplasmic reticulum and Golgi, a large group of secreted proteins lack this peptide and are exported through insufficiently studied nonclassical mechanisms. Our laboratory studies the stress-induced nonclassical export of FGF1 and IL1α, two ubiquitous pro-angiogenic and pro-inflammatory molecules. We hope to understand how multi-protein release complexes are formed, the protein transport mechanisms and how these proteins exit to the extracellular compartment. This knowledge will facilitate the development of new clinical approaches to the regulation of angiogenesis, inflammation and tumor growth.

We also study the interactions between FGF/FGFR, Jagged(Delta)/Notch and thrombin/PAR1 signaling, three major regulatory systems involved in practically all of the aspects of organism development and organ formation. Thrombin stimulation and downregulation of Notch signaling induce FGF1 expression and release, and the acquisition of the angiogenic phenotype by the cells. We hope to unravel the molecular cross-talk involving these molecules and use this  knowledge for treatment of cardiovascular and oncological disorders. Our approaches include transgenic mouse models with conditional expression of FGF1 in endothelial cells and monocytes/macrophages that are being used to study the regulation of FGF1 export in vivo and its effects on tumor formation and tissue repair after ischemia. We also study the cell proliferative response to individual growth factors, including FGFs. We discovered that non-malignant cells respond to FGF by just one proliferative cycle and then indefinitely reside in the G1 phase of the second cycle. Apparently, the limitation of proliferative responseto growth factors may be needed in the organism to prevent tissue hyperplasia, and we are exploring the molecular processes underlying this limitation.

Lab Members

Doreen Kacer, Research Technician Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research