Henry Wortis, MD

Henry Wortis, MD

Professor of Integrative Physiology & Pathobiology



BSc, Zoology, University of Wisconsin, Madison
MD, Albert Einstein College of Medicine
Postdoctoral Training, Stanford University; National Institute for Medical Research, Mill Hill


Campus: Boston
Office: Jaharis 807
Laboratory: Jaharis 801

Contact Information

Office Phone: 617-636-6718
Lab Phone: 617-636-6736
E-mail   Send an e-mail


Research Website  Lab Research Page
Recent Publications  Abstract in PubMed 

Graduate Programs

Genetics, Immunology


Research Synopsis

We are intrigued by the longstanding observation that as people age they often become more susceptible to infectious diseases. The changes in the immune system that underlie the increased susceptibility are poorly understood. We have undertaken studies that use genetic analysis to reveal the immune mechanisms that change with age. To do this we study a human pathogen which has a dramatically different course in people above and below the age of 50. We have identified a mouse strain that also shows an age-related decrease in resistance to this pathogen. We have identified chromosome regions containing genes responsible for resistance in young mice. Intriguingly, genetic studies of old mice reveal that a different set of loci contribute to resistance. We are using a combination of immunological and genetic tools to identify the contributing genes and the mechanisms that they control.


Lab Members

Edouard Vannier, Assistant Professor of Medicine, Collaborator Send an e-mail  Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research