Guo-fu Hu, PhD

Guo-fu

Professor of Medicine

 

Education

BS, Chemistry, Zhejiang University
PhD, Biochemistry, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
Postdoctoral Training, Harvard Medical Scool

Location

Campus: Boston
Office: 75 Kneeland, 10th Floor
Laboratory: 75 Kneeland, 10th Floor

Contact Information

Office Phone: 617-636-4776
Lab Phone: 617-636-7585
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

The main interest of the lab is regulation of angiogenesis in cancer and neurodegeneration. We are focusing on the mechanism and function of angiogenin (ANG) as well as its receptor in prostate cancer and in amyotrophic lateral sclerosis (ALS). ANG is a 14 kDa angiogenic ribonuclease that is upregulated in cancers, especially in prostate cancers and gliobalstomas, and is downregulated in neurodegenerative diseases such as ALS and Parkinson's. Moreover, loss-of-function mutations in the coding region of ANG have been identified in ALS and PD patients. In response to growth stimuli, ANG undergoes nuclear translocation and stimulates ribosomal RNA (rRNA) transcription, which is essential for cell growth and proliferation. However, when the cells are under stresses, ANG is accumulated in stress granules and mediates the production of tiRNA, which reprogram protein translation and promote cell survival. Thus, excessive ANG action underlies uncontrolled cell proliferation and sustained growth as manifested in cancer whereas its insufficiency might be a pathogenesis of degenerative diseases which are characterized as decreased survival and premature death. We are studying the mechanisms and regulation of ANG action and exploring therapeutic opportunities of ANG inhibitors and activators in cancers and in neurodegenerative diseases.

 

Lab Members

Liang Yuan, PhD Student in Cell, Molecular & Developmental Biology Send an e-mail  Lab Research Page
Shuping Li, Instructor, Medicine  Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research