Guo-fu Hu, PhD

Guo-fu

Professor of Medicine

 

Education

BS, Chemistry, Zhejiang University
PhD, Biochemistry, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
Postdoctoral Training, Harvard Medical Scool

Location

Campus: Boston
Office: 75 Kneeland, 10th Floor
Laboratory: 75 Kneeland, 10th Floor

Contact Information

Office Phone: 617-636-4776
Lab Phone: 617-636-7585
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

The main interest of our lab is how RNA processing is regulated in physiological conditions and how it is dysregulated in cancers and in neurodegenerative diseases. We are focusing on the functions and mechanisms of angiogenin (ANG) and ribonuclease 4 (RNASE4), two members of the pancreatic ribonuclease superfamily, in regulating RNA biogenesis. ANG is universally up-regulated in human cancers and is down-regulated and/or loss-of-function mutated in amyotrophic lateral sclerosis (ALS) and Parkinson’s disease. ANG binds to its cell surface receptor plexin-B2 (PLXNB2), is internalized, and translocated to different subcellular compartments to mediate distinct RNA processing events. Under growth conditions and in differentiated cells, ANG is translocated to nucleus where it accumulates in nucleolus to promote ribosomal RNA (rRNA) transcription and stimulate cell growth and proliferation. Under stress conditions and in primitive cell types, ANG is translocated to stress granules and mediates the production of tRNA-derived stress-induced small RNA (tiRNA) that suppresses protein translation and enhances cell survival. We are studying the molecular mechanism of ANG-mediated RNA processing and how this can be harnessed for therapeutic purposes in cancers and in neurodegenerative diseases.

 

Lab Members

Liang Yuan, PhD Student in Cell, Molecular & Developmental Biology Send an e-mail  Lab Research Page
Shuping Li, Instructor, Medicine  Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research