Gregory Cox, PhD

Associate Professor of Medicine

 

Education

BS, Cellular & Molecular Biology, Humboldt State University
PhD, Human Genetics, University of Michigan, Ann Arbor
Postdoctoral Training, The Jackson Laboratory

 

Location

Campus: The Jackson Laboratory, Bar Harbor, ME
Office: Bldg 21, 3380
Laboratory: Bldg 21, 3315

Contact Information

Office Phone: 207-288-6502
Lab Phone: 207-288-6305
E-mail   Send an e-mail

 

Graduate Programs

Genetics

 

Research Synopsis

Our lab uses mouse models to identify the molecular pathways underlying degenerative motor neuron diseases and degenerative muscle diseases that affect people. One interest relates to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease). We cloned the gene for neuromuscular degeneration to create a mouse model for a lethal infantile form of SMA known as spinal muscular atrophy with respiratory distress and identified a modifier gene that decreases disease severity in the mice. Our studies on degenerative muscle diseases similar to muscular dystrophy in humans, have led us to identify an important mutation to the muscle-specific titin gene.  This mouse strain is a novel model of progressive muscular dystrophy and may also be a model for human tibial muscular dystrophy and limb-girdle muscular dystrophy type 2J. We also identified the mutation for a new form of rostrocaudal muscular dystrophy that affects skeletal muscle tissues in a unusual front-to-back progression.

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research