Giuseppina Tesco, MD, PhD


Associate Professor of Neuroscience



MD, University of Florence
PhD, Neuroscience, University of Florence
Postdoctoral Training, Harvard Medical School


Campus: Boston
Office: Stearns 328A
Laboratory: Arnold 305

Contact Information

Office Phone: 617-636-4050
Lab Phone: 617-636-0938
E-mail   Send an e-mail


Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs



Research Synopsis

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-beta-peptides derived from serial proteolysis of the amyloid precursor protein by BACE1 and gamma-secretase. Our studies have revealed a novel mechanism of BACE1 regulation mediated by the BACE1-interacting molecule GGA3. We are probing the molecular mechanisms with a long range goal of understanding AD pathogenesis.


Lab Members

Won Hee Kim, Postdoctoral Scholar Send an e-mail  Lab Research Page
Sylvia Lombardo, Postdoctoral Scholar  Send an e-mail  Lab Research Page
Selene Lomoio, Postdoctoral Scholar  Send an e-mail Lab Research Page
Rachel Willen, Research Assistant Send an e-mail Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research