Professor of Developmental, Molecular & Chemical Biology
BS, Chemistry, Brooklyn Polytechnic Institute
PhD, Biology, MIT
Postdoctoral Training, Institut de Recherche Scient sur le Cancer; Tufts University School of Medicine
Office: Jaharis 808
Laboratory: Jaharis 801
Office Phone: 617-636-4091
Lab Phone: 617-636-4061
Biochemistry, Cell, Molecular & Developmental Biology
I maintain an active research program and participate in graduate training through teaching. I no longer accept dissertation students.
For over 25 years, our research has focused on elucidating the roles of nuclear oncogenes in cancer. My group has made seminal contributions to our understanding of the Myc oncogene, including the first demonstration of dysregulated cell cycle control of c-Myc gene expression in cancers driven by Ras signaling and the ability of c-Myc to prevent differentiation of cells, which has been shown critical for maintenance of the undifferentiated phenotype of stem cells. Our finding that c-Myc gene transcription is regulated by NF-κB led us to focus on this family of transcription factors. We discovered that NF-κB protects B cells from apoptosis and made the unexpected observation that NF-κB is aberrantly expressed in breast cancer and promotes tumor cell survival, which has been extended to many cancers. These findings opened the way to targeting NF-κB pathways for cancer treatment. Currently the lab is investigating the mechanisms of activation of NF-κB, the cross-talk between estrogen receptor a and NF-κB and identifying downstream NF-κB targets mediating a more invasive phenotype in breast cancer, and the mechanisms of action of the novel tumor suppressor protein lysyl oxidase propeptide, and the anti-tumorigenic effects of green tea polyphenols.
Sonia Das, Postdoctoral Scholar
Nora Mineva, Research Associate
Ninon Becquart, PREP Scholar