Associate Professor of Integrative Physiology & Pathobiology
BA, Biology, New York University
MS, Biology, New York University
PhD, Cell Biology & Physiology, New York University
Postdoctoral Training, Albert Einstein College of Medicine
Office: M&V 813A
Laboratory: M&V 8
Office Phone: 617-636-7965
Lab Phone: 617-636-8045
Research Web Site
Cell, Molecular & Developmental Biology, Cellular & Molecular Physiology
I maintain an active laboratory but do not accept dissertation students.
We are delineating the mechanisms by which two genetic diseases (cystic fibrosis and autosomal dominant polycystic kidney) cause liver disease in patients. We have shown that both diseases cause a common dysfunction of the apical membrane anion exchanger found in biliary cells. We hypothesize that protein-protein interaction at the apical membrane of cells is important for the regulation of many cell functions including that of the anion exchanger. We are investigating how altered protein-protein interaction is affected by these diseases. We also are looking at their regulators and the anion exchanger cause of hepatobiliary disease.
Shelley Grubman, Research Assistant Professor
Willem Louis, Research Assistant