Douglas Jefferson, PhD

Douglas Jefferson, PhD

Associate Professor of Integrative Physiology & Pathobiology



BA, Biology, New York University
MS, Biology, New York University
PhD, Cell Biology & Physiology, New York University
Postdoctoral Training, Albert Einstein College of Medicine


Campus: Boston
Office: M&V 813A
Laboratory: M&V 8

Contact Information

Office Phone: 617-636-7965
Lab Phone: 617-636-8045
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology, Cellular & Molecular Physiology


Research Synopsis

I maintain an active laboratory but do not accept dissertation students.

We are delineating the mechanisms by which two genetic diseases (cystic fibrosis and autosomal dominant polycystic kidney) cause liver disease in patients. We have shown that both diseases cause a common dysfunction of the apical membrane anion exchanger found in biliary cells. We hypothesize that protein-protein interaction at the apical membrane of cells is important for the regulation of many cell functions including that of the anion exchanger. We are investigating how altered protein-protein interaction is affected by these diseases. We also are looking at their regulators and the anion exchanger cause of hepatobiliary disease.


Lab Members

Shelley Grubman, Research Assistant Professor Send an e-mail
Willem Louis, Research Assistant Send an e-mail

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research