Don M Wojchowski, PhD

Professor of Medicine

 

Education

BA, Biology, Colby College
PhD, Cell Biology & Zoology, University of Massachusetts, Amherst
Postdoctoral Training, Harvard Medical School

Location

Campus: MMCRI, Scarborough, ME
Laboratory: 10325-10327

Contact Information

Office Phone: 207-396-8347
Lab Phone: 207-396-8258
E-mail   Send an e-mail

 

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

One prime focus of ongoing investigations is on key regulators of erythropoiesis, especially within clinically relevant anemia contexts. EPO/EPOR effects and molecular action mechanisms are a major highlight. Using combined approaches of knocked-in EPOR alleles, primary progenitor cell systems, transcriptome and phosphoproteomic analyses, we have discovered intriguing new major EPOR targets including cyclin G2 (a cell cycle brake); Podocalyxin (a cell surface adhesion/migration factor); Spi2A (an atypical intracellular serpin); TRIB2 & TRIB3 molecular adaptors; and “RHEX” as a novel component of the human EPOR. For each, we have developed novel knockout mouse models and/or primary human progenitor cell GOF / LOF systems with exciting phenotypes exhibited (as recent examples, see Verma, et al, 2014. J Exp Med 211: 1715-1722 Abstract in PubMed and Dev et al, 2013. J Exp Med. 210: 225-232 Abstract in PubMed). In addition, aggressive phosphoproteomic analyses are revealing important new EPO targets and transducers specific to human EPOR/JAK2 complexes. The importance of such work is underlined further by EPO's ability to cytoprotect ischemically injured cardiac, neural and renal tissues; and to modulate tumorigenesis. In addition, novel EPO mimetics are emerging with distinct EPOR activation properties that merit mechanistic attention as they enter the clinic.

Lab Members

Ed Jachimowicz, Laboratory Manager Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research