David Thorley-Lawson, PhD

David Thorley-Lawson, PhD

Professor of Integrative Physiology & Pathobiology

 

Education

BS, Biology, University of East Anglia
PhD, Biochemistry, National Institute for Medical Research
Postdoctoral Training, Dana Farber Cancer Institute

Location

Campus: Boston
Office: Jaharis 529B
Laboratory: Jaharis 5

Contact Information

Office Phone: 617-636-2726
Lab Phone: 617-636-6936
E-mail   Send an e-mail

Links

Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Genetics, Immunology

 

Research Synopsis

We are studying the mechanism of persistence of the oncogenic human herpes virus Epstein-Barr virus. EBV infects >90% of the human population and persists benignly for life. Sometimes, however the virus is associated with cancers including Hodgkin's, Burkitt's and immunoblastic lymphoma and nasopharyngeal and gastric carcinoma. We found that the virus infects B lymphocytes and drives them to proliferate and differentiate so that it can establish persistent infection in memory B cells. When this process is disrupted the proliferative intermediates can give rise to tumors. We are analyzing the signaling pathways that regulate benign persistence and what changes to produce EBV associated tumors.

 

Lab Members

Nicole Castagnozzi, PhD Student in Immunology Send an e-mail 
Charles Torgbor, PhD Student in Immunology Send an e-mail   Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research