David Harrison, PhD

Professor of Medicine

 

Education

BS, Chemistry, Bates College
PhD, Inorganic Chemistry, Stanford University
Postdoctoral Training, The Jackson Laboratory

 

Location

Campus: The Jackson Laboratory, Bar Harbor, ME
Office: Snell 3310
Laboratory: Snell 3275

Contact Information

Office Phone: 207-288-6357
Lab Phone: 207-288-6360
E-mail   Send an e-mail

 

Graduate Programs

Genetics

 

Research Synopsis

The Harrison research group has two focus areas. We investigate aging in mouse models, focusing on processes that have the potential to retard aging and prolong health. For example, one line of research investigates mutations that reduce IGF-1 and insulin function. Such mutations can increase life span and delay certain aspects of aging, especially development of cancer. Now we are developing models that combine multiple mutations. We also study hematopoietic stem cells (HSCs) and other adult stem cells, which constantly proliferate and differentiate to maintain tissue functions throughout life. If aging exhausts the function of adult stem cells, the balance between damage and repair is disrupted and tissue functions become defective. Our group has found that genetic mechanisms protect hematopoietic stem cells from exhaustion in some mouse strains. Now our focus is to define the specific mechanisms. Our long-term goal is to promote healthful aging in humans, either by delaying normal aging processes or by minimizing or eliminating diseases of aging.

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research