David J Greenblatt, MD

David

Louis Lasagna, MD Professor
Professor of Immunology

 

Education

BA, Mathematics, Amherst College
MD, Harvard Medical School
Postdoctoral Training, Harvard Medical School

 

Location

Campus: Boston
Office: M&V 606
Laboratory: M&V 605

Contact Information

Office Phone: 617-636-6997
Lab Phone: 617-636-6949
E-mail   Send an e-mail

Links

Research  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Pharmacology

 

Research Synopsis

Our research work has a focus on the following areas: molecular and clinical pharmacokinetics/pharmacodynamics; genetic and environmental factors regulating drug metabolism by Cytochromes P450 and glucuronosyl transferases, and energy-dependent transport by P-glycoprotein and other transporters; mechanisms, consequences, and in vitro prediction of metabolic drug-drug interactions attributable to enzyme inhibition and induction; effect of age, gender, body habitus, and dietary composition on drug disposition and response; drug interactions involving nutrients and natural substances; molecular and clinical determinants of ligand binding and pharmacodynamic response to centrally-acting drugs. Principal techniques used in the laboratory include: high-pressure liquid chromatography (HPLC) and HPLC with mass spectroscopy for quantitation of drugs and metabolites; in vitro drug metabolism models based on human liver microsomal preparations and recombinant human enzymes; genetic identification and quantitation of single nucleotide polymorphisms altering drug metabolism phenotype; nonlinear regression procedures for pharmacokinetic/pharmacodynamics simulation and modeling.

Lab Members

Mia Angeli, MS Student in Pharmacology & Drug Development  Send an e-mail Lab Research Page
Jerold Harmatz, Research Assistant Professor Send an e-mail
Zhijun Ma, MS Student in Pharmacology & Drug Development  Send an e-mail Lab Research Page
Xiao Yu, MS Student in Pharmacology & Drug Development  Send an e-mail Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research