Daniel Jay, PhD

Daniel Jay, PhD

Professor of Developmental, Molecular & Chemical Biology



BS, Biochemistry & Chemistry, University of Toronto
PhD, Biochemistry & Molecular Biology, Harvard University
Postdoctoral Training, Harvard University


Campus: Boston
Office: M&V 714
Laboratory: M&V 709

Contact Information

Office Phone: 617-636-6714
Lab Phone: 617-636-2957
E-mail   Send an e-mail


Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental BiologyNeuroscience


Research Synopsis

We developed Chromophore-Assisted Laser Inactivation (CALI) to inactivate specific proteins in living cells at precise times and location. We used CALI with antibody libraries in a high throughput and automated fashion to discover new proteins that act in cancer cell invasiveness identified an extracellular form of Heat Shock Protein 90 (Hsp90) that acts to activate pro-invasive proteins in the tumor microenvironment to increase invasion, the first step in metastasis. We are currently pursuing how this activation occurs and whether inhibition of extracellular Hsp90 could be a novel treatment to reduce metastasis of breast cancer.

Lab Members

Aaron Bernstein, PhD Student in Cellular & Molecular Physiology  Send an e-mail  Lab Research Page
Pragya Singh, PhD Student in Cell, Molecular & Developmental Biology Send an e-mail  Lab Research Page
Daniel Wong, PhD Student in Cellular & Molecular Physiology Send an e-mail  Lab Research Page

Apply to the Sackler School


The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research