Cynthia Leveille-Webster, DVM

Cynthia Leveille-Webster, DVM

Professor of Clinical Sciences

 

Education

BS, Biology, Simmons College
DVM, Cornell University
Postdoctoral Training, Tufts University

Location

Campus: Grafton
Laboratory: Foster Hospital for Small Animals

Contact Information

Office Phone: 508-839-7950
Lab Phone: 508-887-4711
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology, Cellular & Molecular Physiology 

 

Research Synopsis

My lab is interested in defining the signaling pathways which control cAMP mediated cytoprotection in hepatocytes. During many forms of liver disease bile formation is slowed and hepatocytes retain many endogenous toxins including bile acids. Bile acid retention leads to hepatocyte apoptosis and necrosis. We have discovered that pre-treatment of hepatocytes with agents that increase intracellular cAMP protect hepatocytes from the cytotoxic action of bile acids. We have conducted experiments to show that this protection is mediated by a signal transduction pathway that involves cAMP activation of cAMP-GEFs rather than the activation of the classic cAMP/protein kinase A pathway. We are currently characterizing the downstream mediators of this cAMP-GEF pathway. Presently we know that it involves sequential activation of the nonreceptor tyrosine kinase, Src tyrosine kinase, the lipid kinase, phosphoinsitide -3-kinase and the serine/threonine kinase, Akt.

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research