Claire Moore, PhD

claire

Professor of Developmental, Molecular & Chemical Biology

 

Education

BS, Chemistry, MIT
MSc, Neuroscience, MIT
PhD, Microbiology, University of North Carolina, Chapel Hill
Postdoctoral Training, Pasteur Institute; MIT

Location

Campus: Boston
Office: Jaharis 408
Laboratory: Jaharis 401

Contact Information

Office Phone: 617-636-6935
Lab Phone: 617-636-3645
E-mail   Send an e-mail

Links

Research Website: Lab Research Page
Recent Publications:  Abstract in PubMed

Graduate Programs

Biochemistry, Genetics, Molecular Microbiology

 

Research Synopsis

We are interested in the post-transcriptional processing of eukaryotic messenger RNA and its role in the regulation of gene expression. Our research uses genetics, biochemistry, and molecular biology to analyze factors which catalyze cleavage and polyadenylation of mRNA precursor. We want to understand how these factors interact with each other and the RNA substrate to assemble a functional processing complex, as well as how these activities are regulated during the cell cycle or during different growth conditions. Another goal is to examine how the polyadenylation machinery is coordinated with other processes involved in mRNA biosynthesis, such as splicing, transcription termination, and nuclear export. We are also using high throughput screening technology to identify inhibitors of polyadenylation that might lead to new anti-fungal or anti-cancer drugs.

 

Lab Members

Derick Hoskinson, PhD Student in Genetics Send an e-mail  Lab Research Page
Fathima Nazeer, Postdoctoral Scholar Send an e-mail  Lab Research Page
Erika Pearson, Postdoctoral Scholar Send an e-mail  Lab Research Page

Application for 2014 Admission

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