Claire Moore, PhD

claire

Natalie V. Zucker Professor of Developmental, Molecular & Chemical Biology

 

Education

BS, Chemistry, MIT
MSc, Neuroscience, MIT
PhD, Microbiology, University of North Carolina, Chapel Hill
Postdoctoral Training, Pasteur Institute; MIT

Location

Campus: Boston
Office: Jaharis 408
Laboratory: Jaharis 401A

Contact Information

Office Phone: 617-636-6935
Lab Phone: 617-636-3645
E-mail   Send an e-mail

Links

Research Website: Lab Research Page
Recent Publications:  Abstract in PubMed

 

Graduate Programs

Cell, Molecular & Developmental Biology, Genetics, Molecular Microbiology

 

Research Synopsis

My research group studies maturation of eukaryotic mRNA through an essential and conserved process called polyadenylation. Functional mRNAs are not made without this processing step, and cells also use it to regulate gene expression during development, differentiation, or in response to external signals. Our goal is to determine the molecular mechanisms of mRNA polyadenylation, its regulation in response to changes in cell status, and its coordination with other nuclear processes such as transcription and DNA damage repair. We use biochemistry, molecular biology, genetics and whole-genome expression analysis to study these issues. Most eukaryotic genes have multiple poly(A) sites, and choice of poly(A) site can have profound effects on the type and amount of protein made from a particular gene. We are particularly interested in understanding mechanisms that lead to such alternative polyadenylation, both in normal cells and in disease states such as cancer or chronic stress.

 

Lab Members

Daniel Heller, MD, PhD Student in Genetics   Send an e-mail Lab Research Page
Susan Lee, Research Associate  Send an e-mail Lab Research Page
Katarzyna Michaels, Postdoctoral Scholar Send an e-mail Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research