Claire Moore, PhD

claire

Natalie V. Zucker Professor of Developmental, Molecular & Chemical Biology

 

Education

BS, Chemistry, MIT
MSc, Neuroscience, MIT
PhD, Microbiology, University of North Carolina, Chapel Hill
Postdoctoral Training, Pasteur Institute; MIT

Location

Campus: Boston
Office: Jaharis 408
Laboratory: Jaharis 401A

Contact Information

Office Phone: 617-636-6935
Lab Phone: 617-636-3645
E-mail   Send an e-mail

Links

Research Website: Lab Research Page
Recent Publications:  Abstract in PubMed

 

Graduate Programs

Biochemistry, Cell, Molecular & Developmental Biology, Genetics, Molecular Microbiology

 

Research Synopsis

We are interested in the post-transcriptional processing of eukaryotic messenger RNA and its role in the regulation of gene expression. Our research uses genetics, biochemistry, and molecular biology to analyze factors which catalyze cleavage and polyadenylation of mRNA precursor. We want to understand how these factors interact with each other and the RNA substrate to assemble a functional processing complex, as well as how these activities are regulated during the cell cycle or during different growth conditions. Another goal is to examine how the polyadenylation machinery is coordinated with other processes involved in mRNA biosynthesis, such as splicing, transcription termination, and nuclear export. We are also using high throughput screening technology to identify inhibitors of polyadenylation that might lead to new anti-fungal or anti-cancer drugs.

 

Lab Members

Daniel Heller, MD, PhD Student in Genetics   Send an e-mail Lab Research Page
Susan Lee, Research Associate  Send an e-mail Lab Research Page
Katarzyna Michaels, Postdoctoral Scholar Send an e-mail Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research