Caroline Attardo Genco, PhD

Caroline

Arthur E Spiller Professor & Chair of Immunology

 

Education

BS, Biology, State University of New York
MS, PhD, Microbiology, University of Rochester
Postdoctoral Training, Center for Disease Control

Location

Campus: Boston
Office: M&V 201D
Laboratory: Jaharis 5

Contact Information

Office Phone: 617-636-6739
Lab Phone: 617-636-4043
E-mail   Send an e-mail

Links

Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

 

Graduate Programs

Immunology, Molecular Microbiology, Pharmacology

 

Research Synopsis

Research in my laboratory spans basic, translational, and global health specifically as it relates to bacterial pathogens. Areas of focus include the effects of chronic infections on systemic health, sexually transmitted infections, and oral and respiratory infectious diseases. Our studies on chronic inflammation focus on the host adapted pathogen Porphyromonas gingivalis which has been linked to development of systemic inflammatory diseases including rheumatoid arthritis, cancer, and cardiovascular disease. Our laboratory has defined the role of specific innate immune signaling pathways in immune cells that contribute collectively to pathogen-induced chronic inflammation. Using defined animal models of inflammation we are characterizing the roles of innate immune pathways in inflammatory processes in vivo. Work in the area of regulatory mechanisms in bacterial pathogens is focused on understanding mechanisms utilized for bacterial colonization, and in particular in the ability of in vivo environmental factors to modulate bacterial gene expression. Transcriptional regulatory mechanisms have been defined on a global level in the pathogenic Neisseria species. Our translational work has encompassed clinical studies evaluating immunological and microbial responses following N. gonorrhoeae infection in both a US cohort and subjects in China.

 

Lab Members

Robert Berland, Research Associate Send an e-mail  Lab Research Page
Carolyn Kramer, Research Associate Send an e-mail  Lab Research Page
George Papadopulos, PhD Student in Molecular & Translational Medicine Send an e-mail  Lab Research Page
Jessica Ritter, Research Technician Send an e-mail  Lab Research Page
Ashwini Sunkavalli, PhD Student in Cell, Molecular & Developmental Biology Send an e-mail Lab Research Page
Ellen Weinberg, Research Assistant Professor Send an e-mail  Lab Research Page

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research