Calvin Vary, PhD

Calvin

Professor of Medicine

 

Education

BS, North Carolina State University
PhD, Biological Chemistry, Michigan State University
Postdoctoral Training, Syracuse University

Location

Campus: MMCRI, Scarborough, ME
Laboratory: 20321 & 20322

Contact Information

Office Phone: 207-396-8148
Lab Phone: 207-396-8175
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Cell, Molecular & Developmental Biology

 

Research Synopsis

Our laboratory works to understand how endoglin, a TGFβ receptor-associated transmembrane protein, and the TGFβ receptors, regulate the process of angiogenesis and the occurrence of vascular pathology. In humans, mutations in the genes encoding either endoglin, or the TGFβ receptor ALK1, cause the vascular disease hereditary hemorrhagic telangiectasia (HHT). Currently, we are interested in those aspects of endoglin's structure that regulate its phosphorylation by the TGFβ receptors, and how endoglin phosphorylation affects cell physiology within a variety of tissue contexts. Understanding the details of endoglin's function will lead to mechanistic insights into the processes of cell adhesion, migration, and invasion, and will advance our understanding of a variety of complex biological processes, including vascular development, vascular disease, and cancer progression.

 

Lab Members

Barbara Conley, Research Associate Send an e-mail  Lab Research Page
Eric Tweedie, Research Technologist Send an e-mail

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research