Brigitte Huber, PhD

brigitte

Professor of Integrative Physiology & Pathobiology

 

Education

BA, Biology, University of Zurich
MSc, Pharmacology, University of Basel
PhD, Immunogenetics, University of London
Postdoctoral Training, Harvard Medical School

Location

Campus: Boston
Office: Jaharis 523A

Contact Information

Office Phone: 617-636-3989
Lab Phone: 617-636-0804
E-mail   Send an e-mail

Links

Research Web Site  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Immunology

 

Research Synopsis

I am active in graduate education through teaching and service on thesis committees but no longer accept dissertation and rotation students. The work in my lab most recently focused on defining essential features of autoimmunity, using murine model systems. Specifically, we are studying TLR7 transgenic mice, which spontaneously develop systemic lupus erythematosus (SLE). Using conditional ATG5 ko mice, lacking a functional autophagy machinery in dendritic cells and/or B cells, we delineated the role of autophagy in this disease process. As a corollary of this system, we obtained new insights into the inflammatory processes that are initiated by chronic TLR7 stimulation and learn which inflammatory mediators directly influence SLE. A second avenue of investigation involved the analysis of endogenous retroviruses.

 

Apply to the Sackler School

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The priority application deadlines are as follows:

December 1: Basic Science Division PhD Programs

February 15: Building Diversity in Biomedical Sciences

March 31: Post-Baccalaureate Research Program

May 1: Clinical & Translational Science, MS in Pharmacology & Drug Development

June 15: Online Certificate in Fundamentals of Clinical Care Research