Allen Taylor, PhD

Allen

Professor of Nutrition

 

Education

BS, Chemistry, City College of New York
PhD, Organic & Biochemistry, Rutgers University
Postdoctoral Training, University of California, Berkeley

Location

Campus: Boston
Office: HNRCA, 6th Floor
Laboratory: HNRCA, 6th Floor

Contact Information

Office Phone: 617-556-3156
Lab Phone: 617-556-3156
E-mail   Send an e-mail

Links

Research Website  Lab Research Page
Recent Publications  Abstract in PubMed

Graduate Programs

Biochemistry, Cell, Molecular & Developmental Biology

 

Research Synopsis

Our group seeks to determine the relations between dietary carbohydrate intake, protein quality control capacities (ubiquitin proteasome pathway and autophagic lysosomal pathways) and aging in the development of eye lens cataracts and retina diseases. We exploit basic science approaches as well as clinical and epidemiologic approaches to elucidate these relationships. We use human cohorts, animal models, and cell/tissue culture systems. We are revealing how carbohydrate-modified proteins are selectively removed by the proteolytic systems and why and how they are cytotoxic in consumers of higher carbohydrate diets and the elderly. We are using newer methods of metabolomics to identify potential surrogate biomarkers for future intervention studies of age-related macular degeneration (AMD), the major blinding disease of the elderly in the developed countries. In addition, we have a significant interest in developing dietary modifications and pharmaceutical interventions by enhancing protein quality control systems to accelerate clearance of protein aggregates. We also contribute to understanding the impact of the ubiquitin proteasome pathways in regulating lens development and differentiation.

 

Lab Members

Min Lee Chang, Senior Research Assistant Send an e-mail  Lab Research Page
Chung-Jung Chiu, Scientist III, Assistant Professor of Ophthalmology  Send an e-mail Lab Research Page
Kalavathi Dasuri, Postdoctoral Scholar Send an e-mail Lab Research Page
Shuhong Jiang, Postdoctoral Scholar Send an e-mail
Sheldon Rowan, Scientist II, Assistant Professor of Ophthalmology Send an e-mail  Lab Research Page
Fu Shang, Scientist I Send an e-mail  Lab Research Page
Elizabeth Whitcomb, Scientist III Send an e-mail  Lab Research Page

Application for 2016 Admission

Application for 2016 admissions will open on August 15, 2015.